An official website of the United States government

Neuraminidase (Influenza A virus (A/black duck/Australia/702/1978(H3N8)))

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-17
Description
Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moieties on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.

1 Names and Identifiers

1.1 Synonyms

  • Neuraminidase
  • EC 3.2.1.18

1.1.1 MeSH Entry Terms

  • Exo-alpha-Sialidase
  • N-Acylneuraminate Glycohydrolases
  • Oligosaccharide Sialidase
  • Sialidase

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 GlyCosmos Protein

2 Sequence

>sp|P03481|NRAM_I78A0 Neuraminidase (Run BLAST)

MNPNQKIITIGSVSLGLVCLDILLHIISITITVLGLHKNGKQRRCNETVIREDNETVRIEKVTQWHNTNVIEYIEKLEGDHFMNNTEPLCHAKGFALFSKDN

3 Domains

3.1 CDD Domains

4 Literature

4.1 Consolidated References

4.2 NLM Curated PubMed Citations

5 Patents

6 Classification

6.1 MeSH Tree

7 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. NCBI Conserved Domains (CDD)
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
CONTENTS