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Protein-N(pi)-phosphohistidine--D-sorbitol phosphotransferase (EC 2.7.1.198)

Enzyme
Enzyme Class
Dates
  • Modify:
    2025-01-20
Description

This enzyme is a component (known as enzyme II) of a phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS)

The system, which is found only in prokaryotes, simultaneously transports its substrate from the periplasm or extracellular space into the cytoplasm and phosphorylates it

The phosphate donor, which is shared among the different systems, is a phospho-carrier protein of low molecular mass that has been phosphorylated by EC 2.7.3.9

Enzyme II, on the other hand, is specific for a particular substrate, although in some cases alternative substrates can be transported with lower efficiency

The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate

1 Names and Identifiers

1.1 Synonyms

  • D-sorbitol PTS permease
  • Glucitol PTS permease
  • Sorbitol PTS permease

2 Biochemical Reactions

3 Catalytic Activity

[Protein]-N(pi)-phospho-L-histidine + D-sorbitol(Side 1) = [protein]-L- histidine + D-sorbitol 6-phosphate(Side 2)

4 Information Sources

  1. ENZYME
    LICENSE
    Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
    https://enzyme.expasy.org/enzyme.get
  2. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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