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Dermonecrotic toxin LspiSicTox-betaIE3i (Loxosceles spinulosa)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-21
Description
Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (By similarity). This toxin acts on sphingomyelin (SM) (By similarity). It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG) (By similarity). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products (By similarity). Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).

1 Names and Identifiers

1.1 Synonyms

  • Dermonecrotic toxin LspiSicTox-betaIE3i
  • EC 4.6.1.-
  • Phospholipase D
  • PLD
  • Sphingomyelin phosphodiesterase D
  • SMD
  • SMase D
  • Sphingomyelinase D

1.1.1 MeSH Entry Terms

  • Lecithinase D
  • Phosphatidylcholine Phosphohydrolase

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 InterPro Protein

2 Sequence

>sp|C0JB44|B1T1_LOXSN Dermonecrotic toxin LspiSicTox-betaIE3i (Run BLAST)

FALAHMVNDFDILKSYLDEGANGVETDITFSDEGEPEYAFHGVPCDCKRWCRRTVGFNEYLQHVRDLSTPGNPKFREHFIAIVLDLKLNGLSQEALAHGGMRLADKLIAYYWAHGRNATRITFIVSVPKTSEKVFLKTFLEEIKAVGYDDMLSKVAFDFTDNGDFSETQKVFEGLGIHEHIWASDGITNCIPMLFRGTSRLEDLIRQRDVPGYKYISKVYAWTYDKETSVVKALELGVDGVMTNYADFVIGIINKPEHSSKYRLATYQDNPFEKFVKSA

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Biochemical Reactions

5 Literature

5.1 Consolidated References

5.2 NLM Curated PubMed Citations

6 Patents

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Protein
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  2. PubChem
  3. Medical Subject Headings (MeSH)
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    https://www.nlm.nih.gov/copyright.html
  4. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
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    https://www.uniprot.org/help/license
  7. Rhea - annotated reactions database
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    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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