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Serine hydroxymethyltransferase (Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

1 Names and Identifiers

1.1 Synonyms

  • Serine hydroxymethyltransferase
  • SHMT
  • Serine methylase
  • EC 2.1.2.1

1.1.1 MeSH Entry Terms

  • Allothreonine Aldolase
  • Serine Aldolase
  • Serine Hydroxymethylase
  • Serine Hydroxymethyltransferase
  • Serine Transhydroxymethylase
  • Threonine Aldolase

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 InterPro Protein

2 Sequence

>sp|B7GTL3|GLYA_BIFLS Serine hydroxymethyltransferase (Run BLAST)

MTASPLAQKATDAFNAPICETDPEIAELLDSELGRQRNGLEMIASENFVPRAVLQCQGSVLTNKYAEGYPGHRYYGGCEYVDQIETIARERAKALFGAEYVNVQPHSGAQANAAVYQALVKPGDTVLGLALDHGGHLTHGMKINFSGRFYHAEAYGVNPVTFRIDPEIIRQRALETHPAMIIGGWSAYPRIEDFKAMKEIADEVGAKFWVDMAHFAGLVAAGLHPSPVPYADVVSSTSHKTFGGPRSGFILAKQEYAKKLNSSVFPGQQGGPLMHVIAGKAVSFKVAGTPEFKDRMQRTLDGAKILAERLLADDVKANGISVLTGGTDVHLVMVDLRNSEMDGQQGEDLLAACGITINRNTVPFDPRPASVASGLRIGTSALATRGFGPKEYEEVADIIGTALAAGPSADVTALKARVDKLAEDFPLYPDLDQIH

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Biochemical Reactions

5 Literature

5.1 Consolidated References

5.2 NLM Curated PubMed Citations

6 Patents

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    Glycine Hydroxymethyltransferase
    https://meshb.nlm.nih.gov/record/ui?ui=D012696
  4. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
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    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  7. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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