Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence
Pathway
Source
Taxonomic Scope
organism_specific
Taxonomy
Category
pathway
Dates
- Create:2024-05-06
- Modify:2025-02-01
Description
MITF target genes are involved in DNA replication, damage repair and chromosome maintenance and stability (Strub et al, 2011; Giuliano et al, 2010; Seoane et al, 2019; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019). Cells depleted of MITF through siRNA can undergo senescence as a result of accumulating DNA damage. In contrast, cells that are depleted of MITF by overexpression of ATF4 undergo reversible cell cycle arrest but do not undergo senescence, suggesting that ATF4 and translational reprogramming may block the senescence pathway (Giuliano et al, 2010; Falletta et al, 2017; reviewed in Goding and Arnheiter, 2019).
PubChem Protein
GlycoProtein
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- PubChem
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
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