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BBSome-mediated cargo-targeting to cilium

Source
Taxonomic Scope
organism_specific
Category
pathway
Dates
  • Create:
    2019-01-17
  • Modify:
    2025-02-01
Description
The BBSome is a stable complex consisting of 7 Bardet-Biedl proteins (BBS1, 2, 4, 5, 7, 8 and 9) and BBIP10 that has roles in promoting IFT and trafficking proteins to the cilum (Blacque et al, 2004; Nachury et al, 2007; Loktev et al, 2008; Jin et al, 2010; reviewed in Sung and Leroux 2013). The BBSome is the primary effector of ARL6/BBS3, a small GTPase that binds the BBSome in complex with associated membrane proteins that are destined for the ciliary membrane (Jin et al, 2010; Nachury et al, 2007; Zhang et al, 2011; Seo et al, 2011). Components of the BBSome are enriched in TPR and beta-propeller motifs and are thought to form a linear coat on membranes that functions with ARL6 to target proteins to the cilium (Jin et al, 2010; reviewed in Nachury et al, 2010).

1 Identity

1.1 Source

1.2 External ID

2 Interactions

3 Chemicals

4 Proteins

4.1 GlycoProteins

PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein

5 Genes

7 Literature

7.1 Consolidated References

8 Information Sources

  1. Reactome
    LICENSE
    Reactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. identifier mapping data, specialized data files, and interaction data derived from Reactome; the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License apply to all software and code, e.g. relating to the functionality of the reactome.org, derived websites and webservices, the Curator Tool, the Functional Interaction application, SQL and Graph Database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials.
    https://reactome.org/license
  2. PubChem
  3. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
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