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Regulation of TNFR1 signaling

Source
Taxonomic Scope
organism_specific
Category
pathway
Dates
  • Create:
    2019-01-17
  • Modify:
    2025-02-01
Description
Tumor necrosis factor-alpha (TNFa) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). Stimuli and the cellular context dictate cell fate decisions between survival and death which rely on tightly regulated mechanisms with checkpoints on many levels. The TNFR1 signaling is controlled by the interplay between post-translational modifications such as proteolytic processing by active caspases or ubiquitination/deubiquitination by LUBAC or CYLD ubiquitin-editing complexes. TNFR1-mediated NFkappaB activation leads to the pro-survival transcriptional program that is both anti-apoptotic and highly proinflammatory. The constitutive NFkappaB or AP1 activation may lead to excessive inflammation which has been associated with a variety of aggressive tumor types (Jackson-Bernitsas DG et al. 2007; Zhang JY et al. 2007). Thus, the tight regulation of TNFa:TNFR1 signaling is required to ensure the appropriate cell response to stimuli.

1 Identity

1.1 Source

1.2 External ID

2 Interactions

3 Chemicals

4 Proteins

4.1 GlycoProteins

PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein
PubChem Protein
GlycoProtein

5 Genes

7 Literature

7.1 Consolidated References

8 Information Sources

  1. Reactome
    LICENSE
    Reactome is an open source and open access resource, available to anyone and covered by two Creative Commons licenses: the terms of the Creative Commons Public Domain (CC0) License apply to all Reactome annotation files, e.g. identifier mapping data, specialized data files, and interaction data derived from Reactome; the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) License apply to all software and code, e.g. relating to the functionality of the reactome.org, derived websites and webservices, the Curator Tool, the Functional Interaction application, SQL and Graph Database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials.
    https://reactome.org/license
  2. PubChem
  3. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
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