Caffeine Metabolism
Pathway
Source
Taxonomic Scope
organism_specific
Taxonomy
Category
Metabolic
Dates
- Create:2019-05-30
- Modify:2022-05-18
Description
Caffeine is obtained from diet including coffee and other beverages and is absorbed in the stomach and small intestine. In the liver, the cytochrome P450 oxidase enzyme system and specifically CYP1A2 metabolizes caffeine into paraxanthine to increase lipolysis and increase free fatty acids and glycerol levels in the blood, theobromine to dilate blood vessels and increase urine volume and theophylline which relaxes bronchi smooth muscles. In the lysosome, these metabolites undergo further metabolism into methyluric acids before being excreted in the urine. There is genetic variability in the metabolism of caffeine due to the polymorphism of CYP1A2. This variability can affect the pharmacokinetic and pharmacodynamic properties of caffeine and may affect an individual's consumption.
- PathBankLICENSEPathBank is made available under the Open Database License (https://opendatacommons.org/licenses/odbl/1.0/).http://pathbank.org/about
- PubChem
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