An official website of the United States government

vegfaa - vascular endothelial growth factor Aa (zebrafish)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-29
Description
Enables growth factor activity. Involved in phosphorylation. Acts upstream of or within several processes, including circulatory system development; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of vasculature development. Located in extracellular region. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; pleuroperitoneal region; and podocyte. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).

1 Names and Identifiers

1.1 Synonyms

  • vegf
  • vegfa
  • wu:fj82c06
  • vascular endothelial growth factor A-A
  • VEGF-A-A
  • etID309976.16
  • vascular endothelial growth factor A
  • vegf-a

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Wikidata

1.2.5 ZFIN ID

2 Proteins

2.1 Protein Function

Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Required for intersegmental vessel development in the tail during embryogenesis (PMID: 15305301). Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation.

2.2 Protein Isoforms

Isoform
Isoform VEGF165
UniProt ID
RefSeq Accession
Isoform
Isoform VEGF121
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 Diseases and Phenotypes

3.1 Gene-Disease Associations

4 Interactions and Pathways

4.1 Chemical-Gene Interactions

4.2 Interactions

4.3 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

8 Patents

9 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  5. NCBI Gene Expression Omnibus (GEO)
  6. STRING: functional protein association networks
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. The Zebrafish Information Network (ZFIN)
    LICENSE
    ZFIN data and data annotations are licensed under a Creative Commons Attribution 4.0 International License
    https://zfin.atlassian.net/wiki/spaces/general/pages/1942160112/WARRANTY+AND+LIABILITY+DISCLAIMER+OWNERSHIP+AND+LIMITS+ON+USE
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. Wikidata
  11. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
CONTENTS