vegfaa - vascular endothelial growth factor Aa (zebrafish)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-29
Description
Enables growth factor activity. Involved in phosphorylation. Acts upstream of or within several processes, including circulatory system development; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of vasculature development. Located in extracellular region. Is expressed in several structures, including cardiovascular system; mesoderm; nervous system; pleuroperitoneal region; and podocyte. Used to study proteinuria. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human VEGFA (vascular endothelial growth factor A).
- vegf
- vegfa
- wu:fj82c06
- vascular endothelial growth factor A-A
- VEGF-A-A
- etID309976.16
- vascular endothelial growth factor A
- vegf-a
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Required for intersegmental vessel development in the tail during embryogenesis (PMID: 15305301). Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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