sloth1 - sloth 1 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-06
Description
Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Is expressed in organism. Orthologous to human UQCC5 (ubiquinol-cytochrome c reductase complex assembly factor 5).
- BcDNA:RE60462
- CG14429
- CG32736
- Dmel\CG32736
- Sloth1
- CG32736-PA
- CG32736-PB
- sloth1-PA
- sloth1-PB
Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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