shk-1 - Potassium voltage-gated channel protein shk-1 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is expressed in body wall musculature; head ganglion; interneuron; muscle cell; and sensory neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32; episodic ataxia type 1; familial atrial fibrillation; and pulmonary hypertension. Orthologous to several human genes including KCNA1 (potassium voltage-gated channel subfamily A member 1); KCNA10 (potassium voltage-gated channel subfamily A member 10); and KCNA2 (potassium voltage-gated channel subfamily A member 2).
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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