An official website of the United States government

shk-1 - Potassium voltage-gated channel protein shk-1 (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Enables delayed rectifier potassium channel activity. Involved in potassium ion transmembrane transport. Located in plasma membrane. Is expressed in body wall musculature; head ganglion; interneuron; muscle cell; and sensory neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32; episodic ataxia type 1; familial atrial fibrillation; and pulmonary hypertension. Orthologous to several human genes including KCNA1 (potassium voltage-gated channel subfamily A member 1); KCNA10 (potassium voltage-gated channel subfamily A member 10); and KCNA2 (potassium voltage-gated channel subfamily A member 2).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Wikidata

1.1.4 WormBase ID

2 Proteins

2.1 Protein Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Has an important role in repolarization and in regulating the pattern of action potential firing. Isoform a expresses currents in a more depolarized voltage range than isoform d.

2.2 Protein Isoforms

Isoform
Isoform c
UniProt ID
RefSeq Accession
Isoform
Isoform b
UniProt ID
RefSeq Accession
Isoform
Isoform d
UniProt ID
RefSeq Accession
Isoform
Isoform a
UniProt ID
RefSeq Accession
Isoform
Isoform e
UniProt ID
RefSeq Accession
Isoform
Isoform f
UniProt ID
RefSeq Accession
Isoform
Isoform g
UniProt ID
RefSeq Accession

2.3 Protein 3D Structures

2.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.4 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Literature

4.1 Gene-Chemical Co-Occurrences in Literature

4.2 Gene-Gene Co-Occurrences in Literature

4.3 Gene-Disease Co-Occurrences in Literature

5 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. STRING: functional protein association networks
  5. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  6. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  7. Wikidata
  8. WormBase
  9. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
CONTENTS