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sae1 - SUMO1 activating enzyme subunit 1 (zebrafish)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-15
Description
Predicted to enable SUMO activating enzyme activity. Acts upstream of or within definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to be located in nucleus. Predicted to be part of SUMO activating enzyme complex. Predicted to be active in cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1).

1 Names and Identifiers

1.1 Synonyms

  • fa28b04
  • sae2a
  • uble1a
  • wu:fa28b04
  • zgc:86633
  • SUMO-activating enzyme subunit 1
  • SUMO1 activating enzyme subunit 2a
  • ubiquitin-like 1 (sentrin) activating enzyme E1A
  • ubiquitin-like 1-activating enzyme E1A

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Wikidata

1.2.5 ZFIN ID

3 Proteins

3.1 Protein Function

The heterodimer acts as an E1 ligase for sumo1, sumo2, and sumo3. It mediates ATP-dependent activation of sumo proteins followed by formation of a thioester bond between a sumo protein and a conserved active site cysteine residue on uba2/sae2 (By similarity).

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Consolidated References

7.2 Gene-Chemical Co-Occurrences in Literature

7.3 Gene-Gene Co-Occurrences in Literature

7.4 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. NCBI Gene Expression Omnibus (GEO)
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. The Zebrafish Information Network (ZFIN)
    LICENSE
    ZFIN data and data annotations are licensed under a Creative Commons Attribution 4.0 International License
    https://zfin.atlassian.net/wiki/spaces/general/pages/1942160112/WARRANTY+AND+LIABILITY+DISCLAIMER+OWNERSHIP+AND+LIMITS+ON+USE
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. Wikidata
  11. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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