rab7A - Rab GTPase (Dictyostelium discoideum AX4)
- DDBDRAFT_0190210
- DDBDRAFT_0191507
- DDB_0190210
- DDB_0191507
- Rab GTPase
- rab G-Proteins
- rab GTP-Binding Protein
- rab GTPases
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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