pnr - pannier (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and protein heterodimerization activity. Involved in several processes, including heart development; pericardial nephrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including amnioserosa anlage; anterior-posterior subdivision of organism; cardiogenic mesoderm; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including adenocarcinoma (multiple); artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to several human genes including GATA5 (GATA binding protein 5).
- CG3978
- CG3978-PA
- Dmel\CG3978
- GATA
- GATA4
- GATAa
- GATAa/Pannier
- PNR
- Pnr
- dGATAa
- dGATAa/pannier
- l(3)89B3
- prn
- CG3978-PA
- CG3978-PB
- CG3978-PC
- CG3978-PD
- pnr-PA
- pnr-PB
- pnr-PC
- pnr-PD
Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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