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pnr - pannier (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-20
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and protein heterodimerization activity. Involved in several processes, including heart development; pericardial nephrocyte differentiation; and regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including amnioserosa anlage; anterior-posterior subdivision of organism; cardiogenic mesoderm; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including adenocarcinoma (multiple); artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to several human genes including GATA5 (GATA binding protein 5).

1 Names and Identifiers

1.1 Synonyms

  • CG3978
  • CG3978-PA
  • Dmel\CG3978
  • GATA
  • GATA4
  • GATAa
  • GATAa/Pannier
  • PNR
  • Pnr
  • dGATAa
  • dGATAa/pannier
  • l(3)89B3
  • prn
  • CG3978-PA
  • CG3978-PB
  • CG3978-PC
  • CG3978-PD
  • pnr-PA
  • pnr-PB
  • pnr-PC
  • pnr-PD

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 FlyBase ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

2 Proteins

2.1 Protein Function

Transcriptional regulator involved in several developmental processes during embryonic and imaginal disks development. Involved in determining dorsal cell fate. Acts as an essential transcriptional regulator of proneural achaete-scute complex (AS-C) and is required for its spatial regulation during development of the adult peripheral nervous system, and hence for the positioning of neural precursors. It is the only factor to directly activate AS-C genes.

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 BioAssays

3.1 RNAi BioAssays

4 Interactions and Pathways

4.1 Interactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Patents

8 Classification

8.1 Gene Ontology: Biological Process

8.2 Gene Ontology: Cellular Component

8.3 Gene Ontology: Molecular Function

9 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  7. NCBI Gene Expression Omnibus (GEO)
  8. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  9. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  10. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  11. Wikidata
  12. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  13. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
CONTENTS