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par-1 - par-1 (fruit fly)

Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-19
Description
Enables tau-protein kinase activity. Involved in several processes, including establishment of planar polarity; negative regulation of hippo signaling; and oogenesis. Located in several cellular components, including basolateral plasma membrane; fusome; and type I terminal bouton. Is expressed in several structures, including adult head; embryonic/larval anterior midgut; embryonic/larval fat body; fusome; and germline cell. Used to study neurodegenerative disease and visual impairment and progressive phthisis bulbi. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to several human genes including MARK1 (microtubule affinity regulating kinase 1) and MARK2 (microtubule affinity regulating kinase 2).

1 Names and Identifiers

1.1 Synonyms

  • 27C1
  • BcDNA:RH48823
  • CG11960
  • CG16701
  • CG30131
  • CG30132
  • CG8201
  • DPAR-1
  • DPar1
  • Dmel\CG8201
  • EMK
  • MARK
  • PAR-1
  • PAR1
  • Par-1
  • Par1
  • anon-WO0210402.19
  • dMARK
  • dPAR-1
  • dPAR1
  • dPar-1
  • dPar1
  • l(2)27C1
  • l(2)k06323
  • par1
  • C-TAK1-like
  • CG8201-PA
  • CG8201-PH
  • CG8201-PL
  • CG8201-PP
  • CG8201-PQ
  • CG8201-PR
  • CG8201-PS
  • CG8201-PT
  • CG8201-PV
  • CG8201-PW
  • CG8201-PX
  • ELKL motif kinase
  • Par-1
  • Par-1 kinase
  • Par-1 protein kinase
  • lethal (2) 27C1
  • par-1-PA
  • par-1-PH
  • par-1-PL
  • par-1-PP
  • par-1-PQ
  • par-1-PR
  • par-1-PS
  • par-1-PT
  • par-1-PV
  • par-1-PW
  • par-1-PX
  • partitioning defective-1

1.2 Other Identifiers

1.2.1 Alliance Gene ID

1.2.2 FlyBase ID

1.2.3 Wikidata

2 BioAssays

2.1 RNAi BioAssays

3 Interactions and Pathways

3.1 Chemical-Gene Interactions

3.2 Interactions

4 Expression

5 Literature

5.1 Consolidated References

5.2 Gene-Chemical Co-Occurrences in Literature

5.3 Gene-Gene Co-Occurrences in Literature

5.4 Gene-Disease Co-Occurrences in Literature

6 Classification

6.1 Gene Ontology: Biological Process

6.2 Gene Ontology: Cellular Component

6.3 Gene Ontology: Molecular Function

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  6. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  7. NCBI Gene Expression Omnibus (GEO)
  8. Wikidata
  9. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
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