mxl-3 - Protein mxl-3 (Caenorhabditis elegans)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of fatty acid biosynthetic process; and response to food. Acts upstream of with a positive effect on insulin receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in intestine; neurons; and pharynx. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X).
Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability (PMID: 23604316, PMID: 29113111). Binds to the E-box motif 5'-CACGTG-3' (PMID: 19632181). Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis (PMID: 23604316). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression (PMID: 29113111). Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway (PMID: 27487365).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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