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mxl-3 - Protein mxl-3 (Caenorhabditis elegans)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18
Description
Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of fatty acid biosynthetic process; and response to food. Acts upstream of with a positive effect on insulin receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in intestine; neurons; and pharynx. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X).

1 Names and Identifiers

1.1 Other Identifiers

1.1.1 Alliance Gene ID

1.1.2 Bgee Gene ID

1.1.3 Wikidata

1.1.4 WormBase ID

2 Proteins

2.1 Protein Function

Transcription factor which regulates the expression of genes involved in lipid metabolism in response to nutrient availability (PMID: 23604316, PMID: 29113111). Binds to the E-box motif 5'-CACGTG-3' (PMID: 19632181). Under well-fed conditions, binds to the promoter and represses the expression of lipase genes lipl-1, lipl-2, lipl-3 and to a lesser extent lipl-5, thereby preventing lipolysis (PMID: 23604316). In response to a high-glucose diet, promotes fatty acid synthesis, elongation and desaturation by up-regulating transcription factor sbp-1 expression (PMID: 29113111). Under well-fed conditions, acts remotely in the intestine to up-regulate the expression of chemoreceptor srh-234 gene in the ADL sensory neuron, possibly by regulating the insulin signaling pathway (PMID: 27487365).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Chemical-Gene Interactions

3.2 Interactions

4 Expression

5 Literature

5.1 Consolidated References

5.2 Gene-Chemical Co-Occurrences in Literature

5.3 Gene-Gene Co-Occurrences in Literature

5.4 Gene-Disease Co-Occurrences in Literature

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  6. NCBI Gene Expression Omnibus (GEO)
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. Wikidata
  10. WormBase
  11. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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