dx - deltex (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-26
Description
Enables Notch binding activity and ubiquitin protein ligase activity. Involved in several processes, including Notch receptor processing; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of signal transduction. Located in cytosol and nucleus. Is expressed in organism. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1); DTX2 (deltex E3 ubiquitin ligase 2); and DTX4 (deltex E3 ubiquitin ligase 4).
- CG3929
- DMDELTEX
- Deltex
- Dlx
- Dmel\CG3929
- Dx
- CG3929-PA
- dx-PA
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it may also act as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch. May function as a ubiquitin ligase protein in the Notch pathway. Regulates the sorting and degradation of N/Notch via an ESCRT-III dependent endolysosomal pathway (PMID: 22162134).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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