arpc2.L - actin related protein 2/3 complex subunit 2 L homeolog (African clawed frog)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-29
- arpc2
- arpc2-a
- actin-related protein 2/3 complex subunit 2-A
- Actin-related protein 2/3 complex subunit 2-A
- actin related protein 2/3 complex, subunit 2, 34kDa
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PMID: 17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PMID: 17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).
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- PubChem
- Swiss Institute of Bioinformatics Bgee
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