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arpc2.L - actin related protein 2/3 complex subunit 2 L homeolog (African clawed frog)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2024-12-29

1 Names and Identifiers

1.1 Synonyms

  • arpc2
  • arpc2-a
  • actin-related protein 2/3 complex subunit 2-A
  • Actin-related protein 2/3 complex subunit 2-A
  • actin related protein 2/3 complex, subunit 2, 34kDa

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 Xenbase Gene ID

2 Proteins

2.1 Protein Function

Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PMID: 17178911). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PMID: 17178911). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (By similarity).

2.2 Protein Targets

3 Patents

4 Information Sources

CONTENTS