SUMO2 - small ubiquitin-like modifier 2 (chicken)
- small ubiquitin-related modifier 2
- SMT3 suppressor of mif two 3 homolog 2
- SUMO-2
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).
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- PubChem
- NCBI Gene Expression Omnibus (GEO)
- STRING: functional protein association networks
- Swiss Institute of Bioinformatics Bgee
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