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SUMO2 - small ubiquitin-like modifier 2 (chicken)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18

1 Names and Identifiers

1.1 Synonyms

  • small ubiquitin-related modifier 2
  • SMT3 suppressor of mif two 3 homolog 2
  • SUMO-2

1.2 Other Identifiers

1.2.1 Bgee Gene ID

1.2.2 VEuPathDB ID

3 Proteins

3.1 Protein Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).

3.2 Protein Targets

4 Interactions and Pathways

4.1 Interactions

4.2 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 Gene-Chemical Co-Occurrences in Literature

7.2 Gene-Gene Co-Occurrences in Literature

7.3 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Information Sources

CONTENTS