STT3B - STT3 oligosaccharyltransferase complex catalytic subunit B (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-26
Description
The protein encoded by the STT3B gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Involved in several processes, including ERAD pathway; co-translational protein modification; and protein N-linked glycosylation via asparagine. Located in endoplasmic reticulum. Part of oligosaccharyltransferase complex. Implicated in congenital disorder of glycosylation Ix.
- CDG1X
- SIMP
- STT3-B
- dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B
- STT3, subunit of the oligosaccharyltransferase complex, homolog B
- STT3B, catalytic subunit of the oligosaccharyltransferase complex
- STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
- dolichyl-diphosphooligosaccharide protein glycotransferase
- homolog of yeast STT3
- oligosaccharyl transferase subunit STT3B
- source of immunodominant MHC-associated peptides homolog
- stt3b (Tachysurus vachellii)
- STT3B (Brown anole)
- STT3B (black-footed ferret)
- STT3B (European mink)
- stt3b (Onychostoma macrolepis)
- STT3B (Ahaetulla prasina)
- STT3B (red-backed fairy wren)
- stt3b (Triplophysa rosa)
- stt3b (Triplophysa dalaica)
- STT3B (Oenanthe melanoleuca)
- stt3b (little skate)
- STT3B (Chinese forest musk deer)
- STT3B (raccoon dog)
- stt3b (oriental weatherfish)
- STT3B (Leopard gecko)
- STT3B (Pteronotus mesoamericanus)
- STT3B (black-legged kittiwake)
- stt3b (blue catfish)
- STT3B (Aeolian wall lizard)
- STT3B (graceful crag lizard)
- STT3B (lesser prairie-chicken)
- STT3B (takin)
- STT3B (yellow-footed antechinus)
- stt3b (grass carp)
- Stt3b (desert hamster)
- stt3b (rohu)
- STT3B (California condor)
- STT3B (Macaca thibetana thibetana)
- Stt3b (reed vole)
- STT3B (Northern goshawk)
- stt3b (Gulf pipefish)
- STT3B (snow leopard)
- STT3B (rock ptarmigan)
- STT3B (Loggerhead turtle)
- STT3B (Sphaerodactylus townsendi)
- Stt3b (Pacific pocket mouse)
- stt3b (Wuchang bream)
- STT3B (Eurasian river otter)
- Stt3b (gray squirrel)
- STT3B (bobcat)
- stt3b (Silurus meridionalis)
- STT3B (greater spear-nosed bat)
- STT3B (American black bear)
- STT3B (Ring-tailed lemur)
- STT3B (Agile Gracile Mouse Opossum)
- STT3B (Komodo dragon)
- STT3B (Asiatic toad)
- STT3B (American mink)
- stt3b (whitespotted bambooshark)
- STT3B (leopard cat)
- STT3B (wapiti)
- stt3b (Sumatra barb)
- Stt3b (banner-tailed kangaroo rat)
- STT3B (fence lizard)
- STT3B (Arctic fox)
- Stt3b (creeping vole)
- STT3B (rufous-necked snowfinch)
- STT3B (white-rumped snowfinch)
- STT3B (jaguarundi)
- STT3B (common toad)
- STT3B (common frog)
- STT3B (scimitar-horned oryx)
- STT3B (Barn swallow)
- STT3B (large flying fox)
- stt3b (gray bichir)
- STT3B (Eurasian tree sparrow)
- stt3b (fathead minnow)
- STT3B (Reeves's turtle)
- STT3B (Tiger rattlesnake)
- STT3B (striped hyena)
- STT3B (leatherback sea turtle)
- Stt3b (Eurasian water vole)
- stt3b (Cyprinodon tularosa)
- STT3B (Iberian mole)
- STT3B (Jamaican fruit-eating bat)
- STT3B (Sturnira hondurensis)
- stt3b (rainbow trout)
- stt3b (tambaqui)
- STT3B (Kuhl's pipistrelle)
- STT3B (Myotis myotis)
- STT3B (Pallas's mastiff bat)
- STT3B (black swan)
- stt3b (European eel)
- stt3b (Pacific halibut)
- STT3B (common lizard)
- STT3B (Southern elephant seal)
- stt3b (Arkansas darter)
- STT3B (Trachemys scripta elegans)
- stt3b (Atlantic halibut)
- Stt3b (Nile rat)
- STT3B (Gaboon caecilian)
- STT3B (Francois's langur)
- STT3B (greater horseshoe bat)
- STT3B (sea lamprey)
- STT3B (Abingdon island giant tortoise)
- STT3B (vaquita)
- stt3b (orangethroat darter)
- STT3B (tufted duck)
- STT3B (silvery gibbon)
- STT3B (ring-necked pheasant)
- Stt3b (southern multimammate mouse)
- stt3b (pikeperch)
- STT3B (Kakapo)
- STT3B (Microcaecilia unicolor)
- STT3B (Aquila chrysaetos chrysaetos)
- Stt3b (white-footed mouse)
- STT3B (Common wall lizard)
- stt3b (yellow perch)
- STT3B (pale spear-nosed bat)
- STT3B (Steller sea lion)
- STT3B (willow flycatcher)
- STT3B (California sea lion)
- stt3b (yellow catfish)
- stt3b (electric eel)
- stt3b (striped catfish)
- STT3B (burrowing owl)
- STT3B (eastern brown snake)
- STT3B (mainland tiger snake)
- STT3B (brown bear)
- stt3b (goldfish)
- STT3B (emu)
- STT3B (Okarito brown kiwi)
- STT3B (Nothoprocta perdicaria)
- STT3B (red fox)
- STT3B (puma)
- STT3B (dingo)
- STT3B (gelada)
- STT3B (Yangtze finless porpoise)
- STT3B (common vampire bat)
- STT3B (blue tit)
- stt3b (Paramormyrops kingsleyae)
- STT3B (Ugandan red Colobus)
- STT3B (beluga whale)
- STT3B (northern sea otter)
- STT3B (Hawaiian monk seal)
- Stt3b (Mongolian gerbil)
- STT3B (white-rumped munia)
- STT3B (helmeted guineafowl)
- Stt3b (shrew mouse)
- Stt3b (Ryukyu mouse)
- STT3B (koala)
- stt3b (great blue-spotted mudskipper)
- STT3B (central bearded dragon)
- stt3b (swamp eel)
- stt3b (whale shark)
- Stt3b (American beaver)
- stt3b (Japanese flounder)
- STT3B (zebu cattle)
- stt3b (tiger tail seahorse)
- STT3B (great roundleaf bat)
- STT3B (Australian saltwater crocodile)
- STT3B (Gharial)
- STT3B (leopard)
- stt3b (Asian bonytongue)
- STT3B (Nanorana parkeri)
- STT3B (black snub-nosed monkey)
- STT3B (Malayan pangolin)
- STT3B (Panamanian white-faced capuchin)
- stt3b (channel catfish)
- stt3b (Sinocyclocheilus anshuiensis)
- stt3b (Sinocyclocheilus grahami)
- STT3B (Miniopterus natalensis)
- STT3B (Egyptian rousette)
- STT3B (Japanese quail)
- STT3B (Taiwan habu)
- STT3B (Great Tit)
- STT3B (Gekko japonicus)
- stt3b (sheepshead minnow)
- STT3B (cheetah)
- STT3B (Common starling)
- STT3B (ass)
- STT3B (Thamnophis sirtalis)
- STT3B (North Island brown kiwi)
- STT3B (Swan goose)
- Stt3b (Ord's kangaroo rat)
- stt3b (Atlantic herring)
- STT3B (gray mouse lemur)
- STT3B (Coquerel's sifaka)
- STT3B (sooty mangabey)
- STT3B (drill)
- STT3B (Colobus angolensis palliatus)
- STT3B (pig-tailed macaque)
- STT3B (large flying fox)
- STT3B (Arabian camel)
- STT3B (Bactrian camel)
- STT3B (Bison bison bison)
- stt3b (black rockcod)
- STT3B (bald eagle)
- STT3B (Corvus cornix cornix)
- STT3B (golden snub-nosed monkey)
- STT3B (White-tailed tropicbird)
- STT3B (white-throated tinamou)
- STT3B (brown roatelo)
- STT3B (sunbittern)
- STT3B (Buceros rhinoceros silvestris)
- STT3B (Macqueen's bustard)
- STT3B (yellow-throated sandgrouse)
- STT3B (Kea)
- STT3B (chimney swift)
- STT3B (red-crested turaco)
- STT3B (common barn owl)
- STT3B (cuckoo roller)
- STT3B (hoatzin)
- STT3B (white-tailed eagle)
- STT3B (Downy woodpecker)
- STT3B (killdeer)
- STT3B (bar-tailed trogon)
- STT3B (red-throated loon)
- STT3B (Red-legged seriema)
- STT3B (African ostrich)
- STT3B (little egret)
- STT3B (common cuckoo)
- STT3B (great cormorant)
- STT3B (Dalmatian pelican)
- STT3B (crested ibis)
- STT3B (Adelie penguin)
- STT3B (emperor penguin)
- STT3B (Common canary)
- STT3B (rifleman)
- STT3B (carmine bee-eater)
- Stt3b (Upper Galilee mountains blind mole rat)
- STT3B (polar bear)
- STT3B (American crow)
- STT3B (Sunda flying lemur)
- STT3B (Przewalski's horse)
- STT3B (big brown bat)
- STT3B (Philippine tarsier)
- STT3B (green monkey)
- stt3b (elephant shark)
- STT3B (Yangtze River dolphin)
- STT3B (Burmese python)
- stt3b (Mexican tetra)
- STT3B (minke whale)
- STT3B (sperm whale)
- STT3B (tiger)
- STT3B (Green sea turtle)
- STT3B (black flying fox)
- STT3B (Myotis davidii)
- STT3B (Weddell seal)
- stt3b (spotted gar)
- STT3B (American alligator)
- STT3B (alpaca)
- STT3B (Wild Bactrian camel)
- STT3B (Chinese tree shrew)
- STT3B (Chinese soft-shelled turtle)
- STT3B (little brown bat)
- STT3B (water buffalo)
- STT3B (Chinese alligator)
- STT3B (coelacanth)
- STT3B (wild yak)
- STT3B (Brandt's bat)
- STT3B (goat)
- STT3B (Tibetan ground-tit)
- STT3B (rock pigeon)
- STT3B (white-throated sparrow)
- STT3B (Saker falcon)
- STT3B (medium ground-finch)
- Stt3b (long-tailed chinchilla)
- STT3B (western painted turtle)
- STT3B (peregrine falcon)
- STT3B (crab-eating macaque)
- Stt3b (golden hamster)
- STT3B (Collared flycatcher)
- STT3B (mallard)
- Stt3b (naked mole-rat)
- STT3B (domestic ferret)
- STT3B (small Madagascar hedgehog)
- STT3B (European shrew)
- STT3B (American pika)
- STT3B (nine-banded armadillo)
- STT3B (Pacific walrus)
- STT3B (Florida manatee)
- STT3B (killer whale)
- STT3B (western lowland gorilla)
- STT3B (sheep)
- STT3B (domestic cat)
- STT3B (Bolivian squirrel monkey)
- STT3B (olive baboon)
- STT3B (pygmy chimpanzee)
- STT3B (small-eared galago)
- STT3B (Tasmanian devil)
- Stt3b (Chinese hamster)
- Stt3b (domestic guinea pig)
- STT3B (African savanna elephant)
- STT3B (gray short-tailed opossum)
- STT3B (northern white-cheeked gibbon)
- stt3b (green anole)
- STT3B (turkey)
- STT3B (pig)
- stt3b (tropical clawed frog)
- STT3B (giant panda)
- STT3B (Sumatran orangutan)
- STT3B (white-tufted-ear marmoset)
- STT3B (rabbit)
- STT3B (zebra finch)
- STT3B (platypus)
- STT3B (horse)
- STT3B (chimpanzee)
- STT3B (Rhesus monkey)
- STT3B (domestic cattle)
- STT3B (dog)
- STT3B (chicken)
- Stt3b (Norway rat)
- stt3b (zebrafish)
- Stt3b (house mouse)
Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PMID: 31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets (By similarity). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation (PMID: 19167329, PMID: 22607976).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licence
- Gene Curation Coalition (GenCC)LICENSEThe GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.https://thegencc.org/terms.htmlSTT3B
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
- HUGO Gene Nomenclature Committee (HGNC)LICENSENo restrictions are imposed on access to, or use of, the data provided by the HGNC, which are provided to enhance knowledge and encourage progress in the scientific community.https://www.genenames.org/about/
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- NCBI Gene Expression Omnibus (GEO)
- NCBI MedGenLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- NCBI StructureLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- Online Mendelian Inheritance in Man (OMIM)LICENSEThe OMIM database is made available to the general public subject to certain restrictions.https://omim.org/help/copyright
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policies
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/about
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics ResourceLICENSEAll data on VEuPathDB websites are provided freely for public use.https://veupathdb.org/veupathdb/app/static-content/about.html
- Wikidata
- Gene Ontology (GO)LICENSEGene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)http://geneontology.org/docs/go-citation-policy/Biological Processhttp://www.geneontology.org/
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq
- Rhea - annotated reactions databaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
CONTENTS