STEAP4 - STEAP4 metalloreductase (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-08
Description
The protein encoded by the STEAP4 gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Enables several functions, including FAD binding activity; ferric-chelate reductase (NADPH) activity; and heme binding activity. Involved in protein homotrimerization. Located in nucleoplasm and plasma membrane.
- STAMP2
- SchLAH
- TIARP
- TNFAIP9
- metalloreductase STEAP4
- STEAP family member 4
- seven chromosome locus associated with HCC
- six transmembrane prostate protein 2
- six-transmembrane epithelial antigen of prostate 4
- sixTransMembrane protein of prostate 2
- tumor necrosis factor, alpha-induced protein 9
- tumor necrosis-alpha-induced adipose-related protein
Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PMID: 30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PMID: 18381574, PMID: 18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PMID: 19660107). Inhibits anchorage-independent cell proliferation (PMID: 19787193).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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