SPTSSA - serine palmitoyltransferase small subunit A (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-09
Description
Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTA is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]
Contributes to serine C-palmitoyltransferase activity. Involved in protein localization and sphingosine biosynthetic process. Acts upstream of or within ceramide biosynthetic process. Located in endoplasmic reticulum. Part of serine palmitoyltransferase complex. Implicated in hereditary spastic paraplegia 90A and hereditary spastic paraplegia 90B.
- C14orf147
- SPG90A
- SPG90B
- SSSPTA
- small subunit of serine palmitoyltransferase A
- SPTSSA (black-footed ferret)
- SPTSSA (European mink)
- SPTSSA (Ahaetulla prasina)
- SPTSSA (red-backed fairy wren)
- SPTSSA (Oenanthe melanoleuca)
- SPTSSA (raccoon dog)
- SPTSSA (Leopard gecko)
- SPTSSA (Pteronotus mesoamericanus)
- SPTSSA (black-legged kittiwake)
- SPTSSA (Aeolian wall lizard)
- SPTSSA (graceful crag lizard)
- SPTSSA (lesser prairie-chicken)
- SPTSSA (yellow-footed antechinus)
- SPTSSA (California condor)
- SPTSSA (Macaca thibetana thibetana)
- SPTSSA (Northern goshawk)
- SPTSSA (snow leopard)
- SPTSSA (rock ptarmigan)
- SPTSSA (Loggerhead turtle)
- SPTSSA (Sphaerodactylus townsendi)
- SPTSSA (Eurasian river otter)
- SPTSSA (bobcat)
- SPTSSA (greater spear-nosed bat)
- SPTSSA (American black bear)
- SPTSSA (Ring-tailed lemur)
- SPTSSA (ass)
- SPTSSA (Komodo dragon)
- SPTSSA (Asiatic toad)
- SPTSSA (American mink)
- SPTSSA (leopard cat)
- SPTSSA (wapiti)
- SPTSSA (common barn owl)
- SPTSSA (fence lizard)
- SPTSSA (Arctic fox)
- SPTSSA (rufous-necked snowfinch)
- SPTSSA (white-rumped snowfinch)
- SPTSSA (jaguarundi)
- SPTSSA (common toad)
- SPTSSA (common frog)
- SPTSSA (scimitar-horned oryx)
- SPTSSA (Barn swallow)
- SPTSSA (large flying fox)
- SPTSSA (Eurasian tree sparrow)
- SPTSSA (Reeves's turtle)
- SPTSSA (Tiger rattlesnake)
- SPTSSA (striped hyena)
- SPTSSA (dog)
- SPTSSA (leatherback sea turtle)
- SPTSSA (Iberian mole)
- SPTSSA (Jamaican fruit-eating bat)
- SPTSSA (Sturnira hondurensis)
- SPTSSA (Kuhl's pipistrelle)
- SPTSSA (Myotis myotis)
- SPTSSA (Pallas's mastiff bat)
- SPTSSA (black swan)
- SPTSSA (common lizard)
- SPTSSA (pygmy chimpanzee)
- SPTSSA (Trachemys scripta elegans)
- SPTSSA (giant panda)
- SPTSSA (Pantherophis guttatus)
- SPTSSA (Gaboon caecilian)
- SPTSSA (Francois's langur)
- SPTSSA (greater horseshoe bat)
- SPTSSA (sea lamprey)
- SPTSSA (Abingdon island giant tortoise)
- SPTSSA (vaquita)
- SPTSSA (Wild Bactrian camel)
- SPTSSA (tufted duck)
- SPTSSA (silvery gibbon)
- SPTSSA (ring-necked pheasant)
- SPTSSA (Arabian camel)
- SPTSSA (western lowland gorilla)
- SPTSSA (Kakapo)
- SPTSSA (Microcaecilia unicolor)
- SPTSSA (Aquila chrysaetos chrysaetos)
- SPTSSA (platypus)
- SPTSSA (Common wall lizard)
- SPTSSA (pale spear-nosed bat)
- SPTSSA (Steller sea lion)
- SPTSSA (sheep)
- SPTSSA (willow flycatcher)
- SPTSSA (California sea lion)
- SPTSSA (mallard)
- SPTSSA (cheetah)
- SPTSSA (eastern brown snake)
- SPTSSA (mainland tiger snake)
- SPTSSA (brown bear)
- SPTSSA (Nothoprocta perdicaria)
- SPTSSA (dingo)
- SPTSSA (gelada)
- SPTSSA (Yangtze finless porpoise)
- SPTSSA (common vampire bat)
- SPTSSA (domestic cat)
- SPTSSA (Ugandan red Colobus)
- SPTSSA (beluga whale)
- SPTSSA (olive baboon)
- SPTSSA (Philippine tarsier)
- SPTSSA (Hawaiian monk seal)
- SPTSSA (white-rumped munia)
- SPTSSA (helmeted guineafowl)
- SPTSSA (koala)
- SPTSSA (central bearded dragon)
- SPTSSA (zebu cattle)
- SPTSSA (great roundleaf bat)
- SPTSSA (Australian saltwater crocodile)
- SPTSSA (Gharial)
- SPTSSA (Nanorana parkeri)
- SPTSSA (goat)
- SPTSSA (black snub-nosed monkey)
- SPTSSA (Malayan pangolin)
- SPTSSA (Panamanian white-faced capuchin)
- SPTSSA (Egyptian rousette)
- SPTSSA (Japanese quail)
- SPTSSA (Taiwan habu)
- SPTSSA (Great Tit)
- SPTSSA (Gekko japonicus)
- SPTSSA (Common starling)
- SPTSSA (Thamnophis sirtalis)
- SPTSSA (gray mouse lemur)
- SPTSSA (Coquerel's sifaka)
- SPTSSA (sooty mangabey)
- SPTSSA (pig-tailed macaque)
- SPTSSA (Corvus cornix cornix)
- SPTSSA (golden snub-nosed monkey)
- SPTSSA (East African grey crowned-crane)
- SPTSSA (White-tailed tropicbird)
- SPTSSA (white-throated tinamou)
- SPTSSA (brown roatelo)
- SPTSSA (sunbittern)
- SPTSSA (Buceros rhinoceros silvestris)
- SPTSSA (Macqueen's bustard)
- SPTSSA (yellow-throated sandgrouse)
- SPTSSA (Kea)
- SPTSSA (chimney swift)
- SPTSSA (red-crested turaco)
- SPTSSA (cuckoo roller)
- SPTSSA (hoatzin)
- SPTSSA (white-tailed eagle)
- SPTSSA (Downy woodpecker)
- SPTSSA (killdeer)
- SPTSSA (bar-tailed trogon)
- SPTSSA (red-throated loon)
- SPTSSA (Red-legged seriema)
- SPTSSA (Northern fulmar)
- SPTSSA (common cuckoo)
- SPTSSA (great cormorant)
- SPTSSA (Dalmatian pelican)
- SPTSSA (crested ibis)
- SPTSSA (Adelie penguin)
- SPTSSA (Common canary)
- SPTSSA (rifleman)
- SPTSSA (polar bear)
- SPTSSA (American crow)
- SPTSSA (Przewalski's horse)
- SPTSSA (big brown bat)
- SPTSSA (green monkey)
- SPTSSA (Yangtze River dolphin)
- SPTSSA (Burmese python)
- SPTSSA (sperm whale)
- SPTSSA (Green sea turtle)
- SPTSSA (Myotis davidii)
- SPTSSA (American alligator)
- SPTSSA (Chinese soft-shelled turtle)
- SPTSSA (little brown bat)
- SPTSSA (water buffalo)
- SPTSSA (coelacanth)
- SPTSSA (wild yak)
- SPTSSA (Tibetan ground-tit)
- SPTSSA (white-throated sparrow)
- Sptssa (long-tailed chinchilla)
- SPTSSA (western painted turtle)
- SPTSSA (crab-eating macaque)
- SPTSSA (European shrew)
- SPTSSA (Pacific walrus)
- SPTSSA (killer whale)
- SPTSSA (Bolivian squirrel monkey)
- SPTSSA (small-eared galago)
- SPTSSA (African savanna elephant)
- SPTSSA (gray short-tailed opossum)
- SPTSSA (northern white-cheeked gibbon)
- SPTSSA (Sumatran orangutan)
- SPTSSA (white-tufted-ear marmoset)
- SPTSSA (rabbit)
- sptssa (Atlantic salmon)
- SPTSSA (zebra finch)
- SPTSSA (pig)
- SPTSSA (chimpanzee)
- SPTSSA (Rhesus monkey)
- SPTSSA (domestic cattle)
- sptssa (zebrafish)
- Sptssa (Norway rat)
- sptssa (tropical clawed frog)
- SPTSSA (chicken)
- Sptssa (house mouse)
Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases (PMID: 19416851). The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core (PMID: 19416851). Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition (PMID: 19416851, PMID: 33558761). The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PMID: 19416851). Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol (PMID: 23510452).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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