SGSM2 - small G protein signaling modulator 2 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
The protein encoded by the SGSM2 gene is a GTPase activator with activity towards RAB32 and RAB33B, which are regulators of membrane trafficking. The encoded protein inactivates RAB32 and can bind RAB9A-GTP, a protein required for RAB32 activation. [provided by RefSeq, Oct 2016]
Enables GTPase activator activity and small GTPase binding activity. Involved in late endosome to Golgi transport and positive regulation of GTPase activity. Located in melanosome.
- RUTBC1
- RUN and TBC1 domain containing 1
- small G protein signaling modulator 2 protein
Possesses GTPase activator activity towards RAB32, RAB33B and RAB38 (PMID: 21808068, PMID: 26620560). Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation (PMID: 26620560).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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