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SERCA - Sarco/endoplasmic reticulum Ca(2+)-ATPase (fruit fly)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-20
Description
Enables P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and stabilization of membrane potential. Located in sarcoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult central nervous system; embryonic/larval midgut primordium; germline cell; gut section; and muscle cell. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1); ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3).

1 Names and Identifiers

1.1 Synonyms

  • 17136664
  • A4UZU0_DROME
  • ATC1_DROME
  • CA-P60A
  • CG3725
  • Ca-ATPase
  • Ca-P60
  • Ca-P60A
  • Ca-p
  • CaP60A
  • Ca[2+]ATPase
  • Ca[2+]P60A
  • Dmel\CG3725
  • Kum
  • SERCA2
  • Serca
  • Serca2a
  • dSERCA
  • dserca
  • kum
  • l(2)SH0211
  • l(2)k08308ab
  • l(2)k09025
  • serca
  • CG3725-PA
  • CG3725-PB
  • CG3725-PC
  • CG3725-PD
  • CG3725-PE
  • CG3725-PF
  • CG3725-PG
  • CG3725-PH
  • CG3725-PI
  • Ca[2+] ATPase
  • SERCA-PA
  • SERCA-PB
  • SERCA-PC
  • SERCA-PD
  • SERCA-PE
  • SERCA-PF
  • SERCA-PG
  • SERCA-PH
  • SERCA-PI
  • calcium ATPase
  • calcium ATPase at 60A
  • endoplasmic reticulum-specific calcium-transporting ATPase
  • kumbhakarna
  • lethal (2) SH0211
  • organellar-type Ca-ATPase
  • sarco endoplasmic reticulum calcium-ATPase
  • sarco/endoplasmic reticulum-type Ca-2+-ATPase
  • sarcoplasmic endoplasmic reticulum calcium ATPase type 2
  • serca

1.1.1 MeSH Entry Terms

  • ATPase, Calcium
  • Adenosine Triphosphatase, Calcium
  • Adenosinetriphosphatase, Calcium
  • Ca2+ ATPase
  • Ca(2+)-Transporting ATPase
  • Calcium ATPase
  • Calcium-ATPase
  • Calcium Adenosinetriphosphatase

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 Enzyme Commission (EC) Number

1.2.5 FlyBase ID

1.2.6 VEuPathDB ID

1.2.7 Wikidata

3 Proteins

3.1 Protein Function

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

3.2 Protein Isoforms

Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform B
UniProt ID
RefSeq Accession
Isoform
Isoform A
UniProt ID
RefSeq Accession

3.3 Protein 3D Structures

3.3.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.4 Protein Targets

4 BioAssays

4.1 RNAi BioAssays

5 Interactions and Pathways

5.1 Chemical-Gene Interactions

5.2 Interactions

6 Biochemical Reactions

7 Expression

8 Literature

8.1 Consolidated References

8.2 NLM Curated PubMed Citations

8.3 Gene-Chemical Co-Occurrences in Literature

8.4 Gene-Gene Co-Occurrences in Literature

8.5 Gene-Disease Co-Occurrences in Literature

9 Classification

9.1 MeSH Tree

9.2 Gene Ontology: Biological Process

9.3 Gene Ontology: Cellular Component

9.4 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  4. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  5. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  6. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  7. STRING: functional protein association networks
  8. Comparative Toxicogenomics Database (CTD)
    LICENSE
    It is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.
    http://ctdbase.org/about/legal.jsp
  9. FlyBase
    LICENSE
    All annotations and data produced by FlyBase that are accessible from flybase.org are distributed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
    https://wiki.flybase.org/wiki/FlyBase:About#FlyBase_Licenses_and_Availability
  10. NCBI Gene Expression Omnibus (GEO)
  11. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  12. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  13. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  14. Wikidata
  15. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  16. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  17. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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