SERCA - Sarco/endoplasmic reticulum Ca(2+)-ATPase (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Enables P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and stabilization of membrane potential. Located in sarcoplasmic reticulum. Is active in endoplasmic reticulum membrane. Is expressed in several structures, including adult central nervous system; embryonic/larval midgut primordium; germline cell; gut section; and muscle cell. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1); ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2); and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3).
- 17136664
- A4UZU0_DROME
- ATC1_DROME
- CA-P60A
- CG3725
- Ca-ATPase
- Ca-P60
- Ca-P60A
- Ca-p
- CaP60A
- Ca[2+]ATPase
- Ca[2+]P60A
- Dmel\CG3725
- Kum
- SERCA2
- Serca
- Serca2a
- dSERCA
- dserca
- kum
- l(2)SH0211
- l(2)k08308ab
- l(2)k09025
- serca
- CG3725-PA
- CG3725-PB
- CG3725-PC
- CG3725-PD
- CG3725-PE
- CG3725-PF
- CG3725-PG
- CG3725-PH
- CG3725-PI
- Ca[2+] ATPase
- SERCA-PA
- SERCA-PB
- SERCA-PC
- SERCA-PD
- SERCA-PE
- SERCA-PF
- SERCA-PG
- SERCA-PH
- SERCA-PI
- calcium ATPase
- calcium ATPase at 60A
- endoplasmic reticulum-specific calcium-transporting ATPase
- kumbhakarna
- lethal (2) SH0211
- organellar-type Ca-ATPase
- sarco endoplasmic reticulum calcium-ATPase
- sarco/endoplasmic reticulum-type Ca-2+-ATPase
- sarcoplasmic endoplasmic reticulum calcium ATPase type 2
- serca
- ATPase, Calcium
- Adenosine Triphosphatase, Calcium
- Adenosinetriphosphatase, Calcium
- Ca2+ ATPase
- Ca(2+)-Transporting ATPase
- Calcium ATPase
- Calcium-ATPase
- Calcium Adenosinetriphosphatase
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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