Pkm - pyruvate kinase M1/2 (Norway rat)
- Create:2016-09-14
- Modify:2025-01-14
- PK
- PKM12
- Pk3
- Pkm2
- pyruvate kinase PKM
- M2 pyruvate kinase
- pyruvate kinase isozymes M1/M2
- pyruvate kinase muscle isozyme
- pyruvate kinase, muscle
- threonine-protein kinase PKM2
- tyrosine-protein kinase PKM2
- 3,5,3'-triiodothyronine-Binding Protein
- Cytosolic Thyroid Hormone-Binding Protein
- Pyruvate Kinase, M1 Isozyme
- Pyruvate Kinase Muscle Isozyme
- T3-Binding Protein p55
- T4-Binding Protein p55
- Thyroid Hormone-Binding Protein
- Thyroid Hormone-Binding Protein p55
- Thyroid Hormone-Binding Protein p58
- Triiodothyronine-Binding Protein p55
- PKM (human)
- PKM (black-footed ferret)
- PKM (European mink)
- PKM (Ahaetulla prasina)
- PKM (red-backed fairy wren)
- PKM (Oenanthe melanoleuca)
- PKM (Chinese forest musk deer)
- PKM (raccoon dog)
- PKM (Leopard gecko)
- PKM (Pteronotus mesoamericanus)
- PKM (black-legged kittiwake)
- PKM (Aeolian wall lizard)
- PKM (graceful crag lizard)
- PKM (cheetah)
- PKM (lesser prairie-chicken)
- PKM (takin)
- PKM (yellow-footed antechinus)
- PKM (California condor)
- PKM (Macaca thibetana thibetana)
- PKM (Northern goshawk)
- PKM (snow leopard)
- PKM (rock ptarmigan)
- PKM (Loggerhead turtle)
- PKM (Sphaerodactylus townsendi)
- PKM (Eurasian river otter)
- PKM (bobcat)
- PKM (greater spear-nosed bat)
- PKM (American black bear)
- PKM (Ring-tailed lemur)
- PKM (domestic cat)
- PKM (Agile Gracile Mouse Opossum)
- PKM (Komodo dragon)
- PKM (Asiatic toad)
- PKM (American mink)
- PKM (wapiti)
- PKM (fence lizard)
- PKM (Arctic fox)
- PKM (rufous-necked snowfinch)
- PKM (white-rumped snowfinch)
- PKM (common toad)
- PKM (common frog)
- PKM (scimitar-horned oryx)
- PKM (Barn swallow)
- PKM (large flying fox)
- PKM (Eurasian tree sparrow)
- PKM (Reeves's turtle)
- PKM (Tiger rattlesnake)
- PKM (striped hyena)
- PKM (leatherback sea turtle)
- PKM (Iberian mole)
- PKM (Jamaican fruit-eating bat)
- PKM (Sturnira hondurensis)
- PKM (Kuhl's pipistrelle)
- PKM (Myotis myotis)
- PKM (Pallas's mastiff bat)
- PKM (black swan)
- PKM (common lizard)
- PKM (Trachemys scripta elegans)
- PKM (giant panda)
- PKM (Pantherophis guttatus)
- PKM (Gaboon caecilian)
- PKM (Francois's langur)
- PKM (greater horseshoe bat)
- PKM (vaquita)
- PKM (tufted duck)
- PKM (silvery gibbon)
- PKM (alpaca)
- PKM (ring-necked pheasant)
- PKM (Kakapo)
- PKM (Microcaecilia unicolor)
- PKM (Aquila chrysaetos chrysaetos)
- PKM (Common wall lizard)
- PKM (pale spear-nosed bat)
- PKM (Steller sea lion)
- PKM (sheep)
- PKM (willow flycatcher)
- PKM (California sea lion)
- PKM (burrowing owl)
- PKM (eastern brown snake)
- PKM (mainland tiger snake)
- PKM (brown bear)
- PKM (emu)
- PKM (Okarito brown kiwi)
- PKM (Nothoprocta perdicaria)
- PKM (red fox)
- PKM (puma)
- PKM (dingo)
- PKM (gelada)
- PKM (Yangtze finless porpoise)
- PKM (common vampire bat)
- PKM (blue tit)
- PKM (Ugandan red Colobus)
- PKM (beluga whale)
- PKM (Hawaiian monk seal)
- PKM (white-rumped munia)
- PKM (helmeted guineafowl)
- PKM (koala)
- PKM (central bearded dragon)
- PKM (zebu cattle)
- PKM (great roundleaf bat)
- PKM (Australian saltwater crocodile)
- PKM (Gharial)
- PKM (Nanorana parkeri)
- PKM (black snub-nosed monkey)
- PKM (Malayan pangolin)
- PKM (Panamanian white-faced capuchin)
- PKM (Miniopterus natalensis)
- PKM (Japanese quail)
- PKM (Taiwan habu)
- PKM (Great Tit)
- PKM (Gekko japonicus)
- PKM (Common starling)
- PKM (ass)
- PKM (North Island brown kiwi)
- PKM (Swan goose)
- PKM (gray mouse lemur)
- PKM (Coquerel's sifaka)
- PKM (sooty mangabey)
- PKM (drill)
- PKM (Colobus angolensis palliatus)
- PKM (pig-tailed macaque)
- PKM (large flying fox)
- PKM (Arabian camel)
- PKM (Bactrian camel)
- PKM (Bison bison bison)
- PKM (bald eagle)
- PKM (Corvus cornix cornix)
- PKM (golden snub-nosed monkey)
- PKM (East African grey crowned-crane)
- PKM (white-throated tinamou)
- PKM (speckled mousebird)
- PKM (brown roatelo)
- PKM (chuck-will's-widow)
- PKM (Macqueen's bustard)
- PKM (yellow-throated sandgrouse)
- PKM (Kea)
- PKM (chimney swift)
- PKM (red-crested turaco)
- PKM (common barn owl)
- PKM (cuckoo roller)
- PKM (hoatzin)
- PKM (Downy woodpecker)
- PKM (killdeer)
- PKM (bar-tailed trogon)
- PKM (red-throated loon)
- PKM (Red-legged seriema)
- PKM (African ostrich)
- PKM (little egret)
- PKM (common cuckoo)
- PKM (great cormorant)
- PKM (Dalmatian pelican)
- PKM (crested ibis)
- PKM (Adelie penguin)
- PKM (emperor penguin)
- PKM (Common canary)
- PKM (polar bear)
- PKM (American crow)
- PKM (Sunda flying lemur)
- PKM (Przewalski's horse)
- PKM (big brown bat)
- PKM (Philippine tarsier)
- PKM (green monkey)
- PKM (Yangtze River dolphin)
- PKM (Burmese python)
- PKM (minke whale)
- PKM (sperm whale)
- PKM (tiger)
- PKM (Green sea turtle)
- PKM (black flying fox)
- PKM (Myotis davidii)
- PKM (Weddell seal)
- PKM (American alligator)
- PKM (Wild Bactrian camel)
- PKM (Chinese tree shrew)
- PKM (Chinese soft-shelled turtle)
- PKM (little brown bat)
- PKM (water buffalo)
- PKM (Chinese alligator)
- PKM (wild yak)
- PKM (Brandt's bat)
- PKM (goat)
- PKM (Tibetan ground-tit)
- PKM (white-throated sparrow)
- PKM (Saker falcon)
- PKM (medium ground-finch)
- Pkm (long-tailed chinchilla)
- PKM (western painted turtle)
- PKM (peregrine falcon)
- PKM (crab-eating macaque)
- PKM (Collared flycatcher)
- PKM (mallard)
- PKM (domestic ferret)
- PKM (small Madagascar hedgehog)
- PKM (European shrew)
- PKM (American pika)
- PKM (nine-banded armadillo)
- PKM (Pacific walrus)
- PKM (killer whale)
- PKM (western lowland gorilla)
- PKM (Bolivian squirrel monkey)
- PKM (olive baboon)
- PKM (pygmy chimpanzee)
- PKM (small-eared galago)
- PKM (Tasmanian devil)
- PKM (African savanna elephant)
- PKM (northern white-cheeked gibbon)
- PKM (turkey)
- PKM (white-tufted-ear marmoset)
- PKM (zebra finch)
- PKM (Sumatran orangutan)
- PKM (platypus)
- PKM (horse)
- PKM (gray short-tailed opossum)
- PKM (rabbit)
- PKM (chimpanzee)
- PKM (Rhesus monkey)
- pkm (tropical clawed frog)
- PKM (domestic cattle)
- PKM (dog)
- PKLR (chicken)
- Pkm (house mouse)
Catalyzes the final rate-limiting step of glycolysis by mediating the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. The ratio between the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Isoform specifically expressed during embryogenesis that has low pyruvate kinase activity by itself and requires allosteric activation by D-fructose 1,6-bisphosphate (FBP) for pyruvate kinase activity. In addition to its pyruvate kinase activity in the cytoplasm, also acts as a regulator of transcription in the nucleus by acting as a protein kinase. Translocates into the nucleus in response to various signals, such as EGF receptor activation, and homodimerizes, leading to its conversion into a protein threonine- and tyrosine-protein kinase. Catalyzes phosphorylation of STAT3 at 'Tyr-705' and histone H3 at 'Thr-11' (H3T11ph), leading to activate transcription. Its ability to activate transcription plays a role in cancer cells by promoting cell proliferation and promote tumorigenesis (By similarity). Promotes the expression of the immune checkpoint protein CD274 in BMAL1-deficient macrophages. May also act as a translation regulator for a subset of mRNAs, independently of its pyruvate kinase activity: associates with subpools of endoplasmic reticulum-associated ribosomes, binds directly to the mRNAs translated at the endoplasmic reticulum and promotes translation of these endoplasmic reticulum-destined mRNAs (By similarity). Plays a role in caspase independent cell death of tumor cells (By similarity).
Pyruvate kinase isoform expressed in adult tissues, which replaces isoform M2 after birth. In contrast to isoform M2, has high pyruvate kinase activity by itself and does not require allosteric activation by D-fructose 1,6-bisphosphate (FBP) for activity.
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