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PLDALPHA3 - phospholipase D alpha 3 (thale cress)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-07
Description
member of C2-PLD subfamily. Analyses on the gene structures/sequences, overall amino acid sequences, and domain structures indicate that PLDalpha3 is most closely related to other two PLDalphas than to other PLDs. Phylogenetic analysis has not identified a true ortholog for PLDalpha3. Involved in hyperosmotic response.

1 Names and Identifiers

1.1 Synonyms

  • F18G18.110
  • F18G18_110
  • phospholipase D alpha 3

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

1.2.2 GlyCosmos Gene

2 Proteins

2.1 Protein Function

Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond to generate phosphatidic acids (PA) (PMID: 18364466). Active with phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), and phosphatidylserine (PS) as substrates (PMID: 18364466). No activity toward phosphatidylinositol (PI) or PIP2 (PMID: 18364466). Positively mediates plant responses to hyperosmotic stresses and promotes root growth, flowering, and stress avoidance (PMID: 18364466, PMID: 19704505). Not involved in the abscisic acid regulation of stomatal movement and transpirational water loss (PMID: 18364466).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  4. NCBI Gene Expression Omnibus (GEO)
  5. STRING: functional protein association networks
  6. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  7. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  8. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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