Mcad - Medium-chain acyl-CoA dehydrogenase (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-16
Description
Enables medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation and medium-chain fatty acid catabolic process. Located in cytosol and mitochondrion. Is expressed in several structures, including epithelium; germline cell; gut section; mesoderm; and visceral mesoderm derivative. Used to study medium chain acyl-CoA dehydrogenase deficiency. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain).
- ACAD
- CG 12262
- CG12262
- Dmel\CG12262
- MCAD
- mcad
- CG12262-PA
- Mcad-PA
- acyl-CoA dehdrogenase
- medium chain acyl-CoA dehydrogenase
- medium-chain acyl-coenzyme A dehydrogenase
- probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial
- Acyl-coenzyme A Dehydrogenase
- Fatty-acyl CoA Dehydrogenase
- MCACA-Dehydrogenase
- Medium Chain Acyl-CoA Dehydrogenase
- Medium-Chain Acyl-Coenzyme A Dehydrogenase
- Medium-Chain Acyl-CoA Dehydrogenase
- Octanoyl-CoA Dehydrogenase
- Palmitoyl-CoA Dehydrogenase
Medium-chain specific acyl-CoA dehydrogenase that catalyzes the first step of mitochondrial fatty acid beta-oxidation, an aerobic process that breaks down fatty acids into acetyl-CoA and allows the production of energy from fats (PMID: 29563254). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). May contribute to Pink1-mediated regulation of fatty acid and amino acid metabolism, through a mechanism that is independent of its acyl-CoA dehydrogenase activity (PMID: 29563254).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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