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MIS12 - minichromosome instability 12 (mis12)-like protein (thale cress)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-19
Description
encodes a homologue of the yeast (S. pombe) Mis12 (minichromosome instability) protein. MIS12 co-localizes with 180 bp repeats of centromeric DNA throughout the cell cycle with a similar pattern to AtCENH3/HTR12. Neither of these two proteins completely cover the 180 bp regions based on FISH analysis.

1 Names and Identifiers

1.1 Synonyms

  • ARABIDOPSIS MINICHROMOSOME INSTABILITY 12 (MIS12)-LIKE
  • ATMIS12
  • MINICHROMOSOME INSTABILITY 12 (MIS12)-LIKE
  • MINICHROMOSOME INSTABILITY 12 HOMOLOGUE
  • MIS12 HOMOLOGUE
  • MOK9.12
  • MOK9_12

2 Proteins

2.1 Protein Function

Constitutive component of kinetochores that is essential for proper cell division during mitotic cell cycle (Probable). May play a role in the modulation of centromere during meiosis (PMID: 21695238).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

4 Literature

4.1 Gene-Chemical Co-Occurrences in Literature

4.2 Gene-Gene Co-Occurrences in Literature

4.3 Gene-Disease Co-Occurrences in Literature

5 Patents

5.1 Gene-Chemical Co-Occurrences in Patents

5.2 Gene-Gene Co-Occurrences in Patents

5.3 Gene-Disease Co-Occurrences in Patents

6 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. STRING: functional protein association networks
  4. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  5. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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