MIR122 - microRNA 122 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-08
Description
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to act upstream of or within several processes, including BMP signaling pathway; erythrocyte differentiation; and multicellular organismal-level iron ion homeostasis. Located in extracellular exosome. Implicated in hepatocellular carcinoma. Biomarker of hepatitis B; liver disease (multiple); lung cancer; and type 2 diabetes mellitus.
- MIR122A
- MIRN122
- MIRN122A
- hsa-mir-122
- miRNA122
- miRNA122A
- mir-122
- hsa-mir-122a
- microRNA 122a
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