MED15 - Mediator complex subunit 15 (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Predicted to enable transcription coregulator activity. Involved in follicle cell of egg chamber development. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15).
- Arc105
- BcDNA:GH03922
- CG4184
- Dmel\CG4184
- Med15
- Med9/ARC105
- dARC105
- med15
- mediator complex subunit 15
- CG4184-PA
- MED15-PA
- mediator15
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for activated transcription of the MtnA, MtnB and MtnD genes.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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