MCO14 - 4a-hydroxytetrahydrobiopterin dehydratase (Saccharomyces cerevisiae S288C)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-31
Description
Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to several human genes including PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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