MAFG - MAF bZIP transcription factor G (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-14
Description
Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010]
Enables identical protein binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of epidermal cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within adult behavior; in utero embryonic development; and regulation of cell population proliferation. Part of RNA polymerase II transcription regulator complex.
- hMAF
- transcription factor MafG
- basic leucine zipper transcription factor MafG
- v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PMID: 11154691). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites (PMID: 11154691, PMID: 8932385, PMID: 9421508). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor (PMID: 11154691). Transcription factor, component of erythroid-specific transcription factor NFE2L2 (PMID: 11154691). Activates globin gene expression when associated with NFE2L2 (PMID: 11154691). May be involved in signal transduction of extracellular H(+) (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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