LPIN1 - lipin 1 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-28
Description
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, acute recurrent rhabdomyolysis, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. [provided by RefSeq, Mar 2017]
Enables phosphatidate phosphatase activity. Involved in phosphatidic acid metabolic process; phosphatidylethanolamine metabolic process; and triglyceride biosynthetic process. Is active in cytosol and endoplasmic reticulum. Biomarker of morbid obesity.
- PAP1
- phosphatidate phosphatase LPIN1
- LPIN1 (black-footed ferret)
- LPIN1 (European mink)
- LPIN1 (Ahaetulla prasina)
- LPIN1 (red-backed fairy wren)
- LPIN1 (Oenanthe melanoleuca)
- LPIN1 (Chinese forest musk deer)
- LPIN1 (raccoon dog)
- LPIN1 (Leopard gecko)
- LPIN1 (Pteronotus mesoamericanus)
- LPIN1 (black-legged kittiwake)
- LPIN1 (Aeolian wall lizard)
- LPIN1 (graceful crag lizard)
- LPIN1 (lesser prairie-chicken)
- LPIN1 (takin)
- LPIN1 (yellow-footed antechinus)
- LPIN1 (California condor)
- LPIN1 (Macaca thibetana thibetana)
- LPIN1 (Northern goshawk)
- LPIN1 (snow leopard)
- LPIN1 (rock ptarmigan)
- LPIN1 (Loggerhead turtle)
- LPIN1 (Sphaerodactylus townsendi)
- LPIN1 (Eurasian river otter)
- LPIN1 (bobcat)
- LPIN1 (greater spear-nosed bat)
- LPIN1 (American black bear)
- LPIN1 (Ring-tailed lemur)
- LPIN1 (Agile Gracile Mouse Opossum)
- LPIN1 (Komodo dragon)
- LPIN1 (Asiatic toad)
- LPIN1 (American mink)
- LPIN1 (leopard cat)
- LPIN1 (wapiti)
- LPIN1 (fence lizard)
- LPIN1 (Arctic fox)
- LPIN1 (rufous-necked snowfinch)
- LPIN1 (white-rumped snowfinch)
- LPIN1 (jaguarundi)
- LPIN1 (common toad)
- LPIN1 (common frog)
- LPIN1 (scimitar-horned oryx)
- LPIN1 (Barn swallow)
- LPIN1 (large flying fox)
- LPIN1 (Eurasian tree sparrow)
- LPIN1 (Reeves's turtle)
- LPIN1 (Tiger rattlesnake)
- LPIN1 (striped hyena)
- LPIN1 (leatherback sea turtle)
- LPIN1 (Iberian mole)
- LPIN1 (Jamaican fruit-eating bat)
- LPIN1 (Sturnira hondurensis)
- LPIN1 (Kuhl's pipistrelle)
- LPIN1 (Myotis myotis)
- LPIN1 (Pallas's mastiff bat)
- LPIN1 (black swan)
- LPIN1 (common lizard)
- LPIN1 (Southern elephant seal)
- LPIN1 (Trachemys scripta elegans)
- LPIN1 (Pantherophis guttatus)
- LPIN1 (Gaboon caecilian)
- LPIN1 (Francois's langur)
- LPIN1 (greater horseshoe bat)
- LPIN1 (Abingdon island giant tortoise)
- LPIN1 (vaquita)
- LPIN1 (tufted duck)
- LPIN1 (silvery gibbon)
- LPIN1 (ring-necked pheasant)
- LPIN1 (Kakapo)
- LPIN1 (Microcaecilia unicolor)
- LPIN1 (Aquila chrysaetos chrysaetos)
- LPIN1 (Common wall lizard)
- LPIN1 (pale spear-nosed bat)
- LPIN1 (sperm whale)
- LPIN1 (Steller sea lion)
- LPIN1 (willow flycatcher)
- LPIN1 (California sea lion)
- LPIN1 (burrowing owl)
- LPIN1 (eastern brown snake)
- LPIN1 (mainland tiger snake)
- LPIN1 (brown bear)
- LPIN1 (emu)
- LPIN1 (Okarito brown kiwi)
- LPIN1 (Nothoprocta perdicaria)
- LPIN1 (red fox)
- LPIN1 (puma)
- LPIN1 (dingo)
- LPIN1 (gelada)
- LPIN1 (Yangtze finless porpoise)
- LPIN1 (common vampire bat)
- LPIN1 (blue tit)
- LPIN1 (Ugandan red Colobus)
- LPIN1 (beluga whale)
- LPIN1 (Hawaiian monk seal)
- LPIN1 (white-rumped munia)
- LPIN1 (helmeted guineafowl)
- LPIN1 (koala)
- LPIN1 (central bearded dragon)
- LPIN1 (zebu cattle)
- LPIN1 (great roundleaf bat)
- LPIN1 (Australian saltwater crocodile)
- LPIN1 (Gharial)
- LPIN1 (leopard)
- LPIN1 (Nanorana parkeri)
- LPIN1 (black snub-nosed monkey)
- LPIN1 (Malayan pangolin)
- LPIN1 (Panamanian white-faced capuchin)
- LPIN1 (Miniopterus natalensis)
- LPIN1 (Egyptian rousette)
- LPIN1 (Japanese quail)
- LPIN1 (Taiwan habu)
- LPIN1 (Great Tit)
- LPIN1 (Gekko japonicus)
- LPIN1 (cheetah)
- LPIN1 (Common starling)
- LPIN1 (ass)
- LPIN1 (North Island brown kiwi)
- LPIN1 (Swan goose)
- LPIN1 (gray mouse lemur)
- LPIN1 (Coquerel's sifaka)
- LPIN1 (sooty mangabey)
- LPIN1 (drill)
- LPIN1 (Colobus angolensis palliatus)
- LPIN1 (pig-tailed macaque)
- LPIN1 (large flying fox)
- LPIN1 (Arabian camel)
- LPIN1 (Bactrian camel)
- LPIN1 (Bison bison bison)
- LPIN1 (bald eagle)
- LPIN1 (Corvus cornix cornix)
- LPIN1 (golden snub-nosed monkey)
- LPIN1 (East African grey crowned-crane)
- LPIN1 (White-tailed tropicbird)
- LPIN1 (white-throated tinamou)
- LPIN1 (speckled mousebird)
- LPIN1 (brown roatelo)
- LPIN1 (chuck-will's-widow)
- LPIN1 (sunbittern)
- LPIN1 (Buceros rhinoceros silvestris)
- LPIN1 (Macqueen's bustard)
- LPIN1 (yellow-throated sandgrouse)
- LPIN1 (Kea)
- LPIN1 (chimney swift)
- LPIN1 (red-crested turaco)
- LPIN1 (common barn owl)
- LPIN1 (cuckoo roller)
- LPIN1 (hoatzin)
- LPIN1 (white-tailed eagle)
- LPIN1 (Downy woodpecker)
- LPIN1 (killdeer)
- LPIN1 (bar-tailed trogon)
- LPIN1 (red-throated loon)
- LPIN1 (Red-legged seriema)
- LPIN1 (African ostrich)
- LPIN1 (little egret)
- LPIN1 (common cuckoo)
- LPIN1 (great cormorant)
- LPIN1 (crested ibis)
- LPIN1 (Adelie penguin)
- LPIN1 (emperor penguin)
- LPIN1 (Common canary)
- LPIN1 (rifleman)
- LPIN1 (carmine bee-eater)
- LPIN1 (polar bear)
- LPIN1 (American crow)
- LPIN1 (Sunda flying lemur)
- LPIN1 (Przewalski's horse)
- LPIN1 (big brown bat)
- LPIN1 (Philippine tarsier)
- LPIN1 (green monkey)
- LPIN1 (Yangtze River dolphin)
- LPIN1 (Burmese python)
- LPIN1 (minke whale)
- LPIN1 (tiger)
- LPIN1 (Green sea turtle)
- LPIN1 (black flying fox)
- LPIN1 (Myotis davidii)
- LPIN1 (American alligator)
- LPIN1 (alpaca)
- LPIN1 (Wild Bactrian camel)
- LPIN1 (Chinese tree shrew)
- LPIN1 (Chinese soft-shelled turtle)
- LPIN1 (little brown bat)
- LPIN1 (water buffalo)
- LPIN1 (Chinese alligator)
- LPIN1 (wild yak)
- LPIN1 (Brandt's bat)
- LPIN1 (goat)
- LPIN1 (Tibetan ground-tit)
- LPIN1 (rock pigeon)
- LPIN1 (white-throated sparrow)
- LPIN1 (Saker falcon)
- LPIN1 (medium ground-finch)
- Lpin1 (long-tailed chinchilla)
- LPIN1 (western painted turtle)
- LPIN1 (crab-eating macaque)
- LPIN1 (peregrine falcon)
- LPIN1 (Collared flycatcher)
- LPIN1 (mallard)
- LPIN1 (domestic ferret)
- LPIN1 (small Madagascar hedgehog)
- LPIN1 (European shrew)
- LPIN1 (American pika)
- LPIN1 (nine-banded armadillo)
- LPIN1 (Pacific walrus)
- LPIN1 (killer whale)
- LPIN1 (western lowland gorilla)
- LPIN1 (sheep)
- LPIN1 (domestic cat)
- LPIN1 (Bolivian squirrel monkey)
- LPIN1 (olive baboon)
- LPIN1 (pygmy chimpanzee)
- LPIN1 (small-eared galago)
- LPIN1 (Tasmanian devil)
- LPIN1 (African savanna elephant)
- LPIN1 (northern white-cheeked gibbon)
- LPIN1 (giant panda)
- LPIN1 (Sumatran orangutan)
- LPIN1 (white-tufted-ear marmoset)
- LPIN1 (rabbit)
- LPIN1 (zebra finch)
- LPIN1 (pig)
- LPIN1 (platypus)
- LPIN1 (horse)
- LPIN1 (gray short-tailed opossum)
- lpin1a (zebrafish)
- lpin1 (tropical clawed frog)
- LPIN1 (Rhesus monkey)
- LPIN1 (domestic cattle)
- LPIN1 (dog)
- LPIN1 (chimpanzee)
- LPIN1 (chicken)
- Lpin1 (Norway rat)
- Lpin1 (house mouse)
Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PMID: 20231281, PMID: 23426360, PMID: 29765047, PMID: 31695197). Is involved in adipocyte differentiation (By similarity). Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression (By similarity).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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