Klp68D - Kinesin-like protein at 68D (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2024-12-19
Description
Enables cytoskeletal motor activity. Involved in anterograde axonal transport; establishment or maintenance of microtubule cytoskeleton polarity; and sensory perception of smell. Part of microtubule associated complex. Is expressed in several structures, including embryonic central brain neurons; female germline cell; ganglia; gonad; and sensory nervous system primordium. Used to study chromosome 16p11.2 deletion syndrome, 593-kb. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Orthologous to several human genes including KIF3B (kinesin family member 3B).
- CG7293
- DmKlp68D
- Dmel\CG7293
- KIF 3B
- KIF3B
- KLP-5
- KLP5
- KLP68D
- KLP68Ddm
- KLP[[64D/68D]]
- Klp5
- klp68d
- CG7293-PA
- CG7293-PB
- Kinesin-2
- Kinesin1
- Klp68D-PA
- Klp68D-PB
- kinesin II
Plus-end directed microtubule motor that may be used for anterograde axonal transport and could conceivably move cargos in fly neurons different than those moved by kinesin heavy chain or other plus-end directed motors.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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