HCFC1 - host cell factor C1 (human)
- Create:2016-09-14
- Modify:2024-12-21
The HCFC1 gene provides instructions for making a protein, called HCF-1, that helps regulate the activity of other genes. HCF-1 interacts with proteins called transcription factors, which attach (bind) to specific regions of DNA and help control the activity of particular genes.
A specific function of the HCF-1 protein is to control the activity of genes involved in the processing of vitamin B12 (also known as cobalamin), particularly the MMACHC gene. This gene plays a role in the conversion of vitamin B12 into one of two molecules, adenosylcobalamin (AdoCbl) or methylcobalamin (MeCbl). AdoCbl is required for the normal function of an enzyme known as methylmalonyl CoA mutase. This enzyme helps break down certain protein building blocks (amino acids), fats (lipids), and cholesterol. AdoCbl is called a cofactor because it helps methylmalonyl CoA mutase carry out its function. MeCbl is also a cofactor, but for an enzyme known as methionine synthase. This enzyme converts the amino acid homocysteine to another amino acid, methionine. The body uses methionine to make proteins and other important compounds.
HCF-1 helps regulate genes that are important in other cellular processes, such as progression of cells through the step-by-step process it takes to replicate themselves (called the cell cycle). This protein also plays a role in the distribution of cells in developing tissues and organs, including the brain.
- CFF
- HCF
- HCF-1
- HCF1
- HFC1
- MAHCX
- MRX3
- PPP1R89
- VCAF
- XLID3
- host cell factor 1
- VP16-accessory protein
- protein phosphatase 1, regulatory subunit 89
- C1 Host Cell Factor
- Cell Proliferation Factor HCF
- HCFC1 Protein
Transcriptional coregulator (By similarity). Involved in control of the cell cycle (PMID: 10629049, PMID: 10779346, PMID: 15190068, PMID: 16624878, PMID: 23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PMID: 10675337, PMID: 12244100). Coactivator for EGR2 and GABP2 (PMID: 12244100, PMID: 14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together (PMID: 12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PMID: 20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PMID: 20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PMID: 23629655). Modulates expression of homeobox protein PDX1, perhaps acting in concert with transcription factor E2F1, thereby regulating pancreatic beta-cell growth and glucose-stimulated insulin secretion (By similarity). May negatively modulate transcriptional activity of FOXO3 (By similarity).
(Microbial infection) In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
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