H4C2 - H4 clustered histone 2 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-15
Description
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]
A structural constituent of chromatin. Involved in negative regulation of megakaryocyte differentiation and nucleosome assembly. Located in nucleus. Part of CENP-A containing nucleosome.
- H4-16
- H4/I
- H4C1
- H4C11
- H4C12
- H4C13
- H4C14
- H4C15
- H4C16
- H4C3
- H4C4
- H4C5
- H4C6
- H4C8
- H4C9
- H4FI
- HIST1H4B
- histone H4
- H4 histone family, member I
- histone 1, H4b
- histone cluster 1 H4 family member b
- histone cluster 1, H4b
- Histone H3
- Histone H3.3
- Histone H4
- Histone H5
- Histone H7
- Histone
- Histone H2a
- Histone H1
- Histone H1(s)
- Histone H2b
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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