Endov - endonuclease V (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
Enables endodeoxyribonuclease activity, producing 5'-phosphomonoesters and magnesium ion binding activity. Involved in DNA repair. Predicted to be located in cytoplasmic stress granule. Predicted to be active in cytoplasm and nucleolus. Orthologous to human ENDOV (endonuclease V).
- A730011L01Rik
- novel endonuclease V protein
- putative endonuclease FLJ39025 homolog
- Corrective Endonuclease
- Endodeoxyribonuclease (Pyrimidine Dimer)
- Endodeoxyribonuclease VIII
- Endonuclease V
- Endonuclease VIII
Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Active against both single-stranded and double-stranded RNAs. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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