EOGT - EGF domain specific O-linked N-acetylglucosamine transferase (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum lumen. Implicated in Adams-Oliver syndrome.
The EOGT gene provides instructions for making a protein that modifies certain other proteins by transferring a molecule called N-acetylglucosamine to them. This change, called an O-GlcNAc modification, can affect protein stability and regulate several cellular processes, such as signaling in cells and the first step in the production of proteins from genes (transcription). Little is known about the proteins altered by the EOGT protein or what effect the O-GlcNAc modification has on them. Studies suggest that Notch proteins may be modified by EOGT. Notch proteins stimulate signaling pathways important during the development of several tissues throughout the body, including the bones, heart, liver, muscles, and blood cells, among others.
- AER61
- AOS4
- C3orf64
- EOGT1
- EGF domain-specific O-linked N-acetylglucosamine transferase
- AER61 glycosyltransferase
- EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase
- EGF-O-GlcNAc transferase
- extracellular O-linked N-acetylglucosamine transferase
- EOGT (black-footed ferret)
- EOGT (European mink)
- eogt (Onychostoma macrolepis)
- EOGT (Ahaetulla prasina)
- EOGT (red-backed fairy wren)
- eogt (Triplophysa rosa)
- eogt (sansaifugu)
- eogt (Triplophysa dalaica)
- EOGT (Oenanthe melanoleuca)
- eogt (little skate)
- EOGT (Chinese forest musk deer)
- EOGT (raccoon dog)
- eogt (oriental weatherfish)
- EOGT (Leopard gecko)
- eogt (sablefish)
- EOGT (Pteronotus mesoamericanus)
- EOGT (black-legged kittiwake)
- eogt (blue catfish)
- EOGT (Aeolian wall lizard)
- EOGT (graceful crag lizard)
- EOGT (lesser prairie-chicken)
- EOGT (takin)
- eogt (silver crucian carp)
- EOGT (yellow-footed antechinus)
- eogt (grass carp)
- Eogt (desert hamster)
- eogt (rohu)
- EOGT (California condor)
- EOGT (Macaca thibetana thibetana)
- Eogt (reed vole)
- EOGT (Northern goshawk)
- eogt (Gulf pipefish)
- EOGT (snow leopard)
- eogt (brown-marbled grouper)
- EOGT (rock ptarmigan)
- EOGT (Loggerhead turtle)
- EOGT (Sphaerodactylus townsendi)
- Eogt (Pacific pocket mouse)
- eogt (Wuchang bream)
- EOGT (Eurasian river otter)
- eogt (flathead mullet)
- Eogt (gray squirrel)
- eogt (Girardinichthys multiradiatus)
- EOGT (bobcat)
- eogt (Silurus meridionalis)
- eogt (pink salmon)
- EOGT (greater spear-nosed bat)
- EOGT (American black bear)
- EOGT (Ring-tailed lemur)
- EOGT (Agile Gracile Mouse Opossum)
- EOGT (Komodo dragon)
- EOGT (Asiatic toad)
- EOGT (American mink)
- eogt (mandarin fish)
- eogt (western mosquitofish)
- eogt (Senegalese sole)
- eogt (whitespotted bambooshark)
- EOGT (leopard cat)
- EOGT (wapiti)
- eogt (Sumatra barb)
- Eogt (banner-tailed kangaroo rat)
- eogt (leopard coralgrouper)
- EOGT (fence lizard)
- eogt (lake whitefish)
- eogt (humphead wrasse)
- EOGT (Arctic fox)
- Eogt (creeping vole)
- EOGT (rufous-necked snowfinch)
- EOGT (white-rumped snowfinch)
- eogt (Mississippi paddlefish)
- EOGT (jaguarundi)
- EOGT (common toad)
- EOGT (common frog)
- EOGT (scimitar-horned oryx)
- eogt (three-spined stickleback)
- eogt (swordfish)
- EOGT (Barn swallow)
- EOGT (large flying fox)
- eogt (gray bichir)
- EOGT (Eurasian tree sparrow)
- eogt (fathead minnow)
- EOGT (Reeves's turtle)
- EOGT (Tiger rattlesnake)
- EOGT (striped hyena)
- eogt (lake trout)
- eogt (largemouth bass)
- EOGT (leatherback sea turtle)
- Eogt (Eurasian water vole)
- eogt (Rio pearlfish)
- EOGT (Iberian mole)
- eogt (ninespine stickleback)
- EOGT (Jamaican fruit-eating bat)
- eogt (yellowfin seabream)
- EOGT (Sturnira hondurensis)
- eogt (tambaqui)
- EOGT (Kuhl's pipistrelle)
- EOGT (Myotis myotis)
- EOGT (Pallas's mastiff bat)
- eogt (chum salmon)
- EOGT (black swan)
- eogt (European eel)
- eogt (Pacific halibut)
- EOGT (common lizard)
- EOGT (Southern elephant seal)
- eogt (Arkansas darter)
- EOGT (Trachemys scripta elegans)
- eogt (Atlantic halibut)
- eogt (lumpfish)
- Eogt (Nile rat)
- EOGT (Pantherophis guttatus)
- EOGT (Gaboon caecilian)
- eogt (giant grouper)
- EOGT (Francois's langur)
- EOGT (greater horseshoe bat)
- EOGT (sea lamprey)
- EOGT (Abingdon island giant tortoise)
- EOGT (vaquita)
- eogt (green swordtail)
- eogt (orangethroat darter)
- EOGT (tufted duck)
- EOGT (silvery gibbon)
- eogt (blue tilapia)
- EOGT (ring-necked pheasant)
- Eogt (southern multimammate mouse)
- eogt (pikeperch)
- EOGT (Kakapo)
- EOGT (Microcaecilia unicolor)
- EOGT (Aquila chrysaetos chrysaetos)
- eogt (river trout)
- eogt (sockeye salmon)
- eogt (Cottoperca gobio)
- eogt (Siamese fighting fish)
- Eogt (white-footed mouse)
- EOGT (Common wall lizard)
- eogt (yellow perch)
- EOGT (pale spear-nosed bat)
- EOGT (Steller sea lion)
- eogt (Monterrey platyfish)
- EOGT (willow flycatcher)
- EOGT (California sea lion)
- eogt (yellow catfish)
- eogt (electric eel)
- eogt (striped catfish)
- EOGT (burrowing owl)
- EOGT (eastern brown snake)
- EOGT (mainland tiger snake)
- EOGT (brown bear)
- eogt (goldfish)
- EOGT (emu)
- EOGT (Okarito brown kiwi)
- EOGT (Nothoprocta perdicaria)
- EOGT (red fox)
- EOGT (puma)
- EOGT (dingo)
- EOGT (gelada)
- EOGT (Yangtze finless porpoise)
- EOGT (common vampire bat)
- eogt (Chinook salmon)
- eogt (Indian medaka)
- eogt (Salvelinus sp. IW2-2015)
- EOGT (blue tit)
- eogt (Paramormyrops kingsleyae)
- eogt (Seriola lalandi dorsalis)
- eogt (clown anemonefish)
- EOGT (Ugandan red Colobus)
- eogt (greater amberjack)
- EOGT (beluga whale)
- LOC111143973 (northern sea otter)
- EOGT (Hawaiian monk seal)
- Eogt (Mongolian gerbil)
- eogt (rainbow trout)
- EOGT (white-rumped munia)
- EOGT (helmeted guineafowl)
- Eogt (shrew mouse)
- Eogt (Ryukyu mouse)
- EOGT (koala)
- eogt (great blue-spotted mudskipper)
- EOGT (central bearded dragon)
- eogt (swamp eel)
- eogt (whale shark)
- eogt (coho salmon)
- Eogt (American beaver)
- eogt (Japanese flounder)
- EOGT (zebu cattle)
- eogt (tiger tail seahorse)
- EOGT (great roundleaf bat)
- EOGT (Australian saltwater crocodile)
- EOGT (Gharial)
- EOGT (leopard)
- eogt (Asian bonytongue)
- eogt (barramundi perch)
- EOGT (Nanorana parkeri)
- EOGT (black snub-nosed monkey)
- EOGT (Malayan pangolin)
- EOGT (Panamanian white-faced capuchin)
- eogt (channel catfish)
- eogt (mangrove rivulus)
- eogt (Sinocyclocheilus rhinocerous)
- eogt (Sinocyclocheilus grahami)
- EOGT (Miniopterus natalensis)
- EOGT (Egyptian rousette)
- eogt (turquoise killifish)
- EOGT (Japanese quail)
- EOGT (Taiwan habu)
- EOGT (Great Tit)
- EOGT (Gekko japonicus)
- eogt (sheepshead minnow)
- EOGT (cheetah)
- eogt (sailfin molly)
- eogt (shortfin molly)
- EOGT (Common starling)
- EOGT (ass)
- eogt (Atlantic salmon)
- EOGT (Thamnophis sirtalis)
- eogt (Austrofundulus limnaeus)
- EOGT (North Island brown kiwi)
- EOGT (Swan goose)
- Eogt (Ord's kangaroo rat)
- eogt (Atlantic herring)
- EOGT (gray mouse lemur)
- EOGT (Coquerel's sifaka)
- EOGT (sooty mangabey)
- EOGT (drill)
- EOGT (Colobus angolensis palliatus)
- EOGT (pig-tailed macaque)
- EOGT (large flying fox)
- EOGT (Arabian camel)
- EOGT (Bactrian camel)
- eogt (northern pike)
- EOGT (Bison bison bison)
- eogt (black rockcod)
- eogt (large yellow croaker)
- EOGT (bald eagle)
- EOGT (Corvus cornix cornix)
- EOGT (golden snub-nosed monkey)
- EOGT (East African grey crowned-crane)
- EOGT (White-tailed tropicbird)
- EOGT (white-throated tinamou)
- EOGT (brown roatelo)
- EOGT (chuck-will's-widow)
- EOGT (sunbittern)
- EOGT (Buceros rhinoceros silvestris)
- EOGT (Macqueen's bustard)
- EOGT (yellow-throated sandgrouse)
- EOGT (Kea)
- EOGT (chimney swift)
- EOGT (red-crested turaco)
- EOGT (common barn owl)
- EOGT (cuckoo roller)
- EOGT (hoatzin)
- EOGT (white-tailed eagle)
- EOGT (Downy woodpecker)
- EOGT (killdeer)
- EOGT (bar-tailed trogon)
- EOGT (red-throated loon)
- EOGT (Red-legged seriema)
- EOGT (African ostrich)
- EOGT (little egret)
- EOGT (Northern fulmar)
- EOGT (common cuckoo)
- EOGT (great cormorant)
- EOGT (Dalmatian pelican)
- EOGT (crested ibis)
- EOGT (Adelie penguin)
- EOGT (emperor penguin)
- EOGT (Common canary)
- EOGT (rifleman)
- EOGT (carmine bee-eater)
- Eogt (Upper Galilee mountains blind mole rat)
- EOGT (polar bear)
- EOGT (American crow)
- EOGT (Sunda flying lemur)
- EOGT (Przewalski's horse)
- eogt (guppy)
- eogt (tongue sole)
- EOGT (big brown bat)
- EOGT (Philippine tarsier)
- EOGT (green monkey)
- eogt (elephant shark)
- eogt (Amazon molly)
- EOGT (Yangtze River dolphin)
- EOGT (Burmese python)
- eogt (Mexican tetra)
- EOGT (minke whale)
- EOGT (sperm whale)
- EOGT (tiger)
- EOGT (Green sea turtle)
- EOGT (black flying fox)
- EOGT (Myotis davidii)
- EOGT (Weddell seal)
- eogt (spotted gar)
- EOGT (American alligator)
- EOGT (alpaca)
- EOGT (Wild Bactrian camel)
- EOGT (Chinese tree shrew)
- EOGT (Chinese soft-shelled turtle)
- EOGT (little brown bat)
- EOGT (water buffalo)
- EOGT (Chinese alligator)
- EOGT (coelacanth)
- EOGT (wild yak)
- EOGT (Brandt's bat)
- eogt (southern platyfish)
- EOGT (goat)
- EOGT (crab-eating macaque)
- EOGT (Tibetan ground-tit)
- EOGT (rock pigeon)
- EOGT (white-throated sparrow)
- EOGT (Saker falcon)
- EOGT (medium ground-finch)
- Eogt (long-tailed chinchilla)
- EOGT (western painted turtle)
- EOGT (peregrine falcon)
- Eogt (golden hamster)
- EOGT (Collared flycatcher)
- EOGT (mallard)
- Eogt (naked mole-rat)
- EOGT (domestic ferret)
- EOGT (small Madagascar hedgehog)
- EOGT (European shrew)
- EOGT (American pika)
- eogt (zebra mbuna)
- EOGT (nine-banded armadillo)
- EOGT (Pacific walrus)
- EOGT (Florida manatee)
- EOGT (killer whale)
- eogt (Japanese medaka)
- EOGT (western lowland gorilla)
- EOGT (sheep)
- EOGT (domestic cat)
- EOGT (Bolivian squirrel monkey)
- EOGT (olive baboon)
- EOGT (pygmy chimpanzee)
- EOGT (small-eared galago)
- EOGT (Tasmanian devil)
- Eogt (Chinese hamster)
- Eogt (domestic guinea pig)
- eogt (Nile tilapia)
- EOGT (African savanna elephant)
- EOGT (gray short-tailed opossum)
- EOGT (northern white-cheeked gibbon)
- eogt (green anole)
- EOGT (turkey)
- EOGT (giant panda)
- EOGT (Sumatran orangutan)
- EOGT (white-tufted-ear marmoset)
- EOGT (rabbit)
- EOGT (zebra finch)
- EOGT (pig)
- EOGT (platypus)
- EOGT (horse)
- eogt (zebrafish)
- eogt (tropical clawed frog)
- eogt (torafugu)
- EOGT (Rhesus monkey)
- EOGT (domestic cattle)
- EOGT (dog)
- EOGT (chimpanzee)
- Eogt (Norway rat)
- EOGT (chicken)
- Eogt (house mouse)
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Alliance of Genome ResourcesLICENSEAll annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).https://www.alliancegenome.org/privacy-warranty-licensing
- MedlinePlus GeneticsLICENSETerms and conditions of use apply to all persons or organizations that publish or distribute content from the MedlinePlus website.https://medlineplus.gov/about/using/usingcontent/
- BioGRIDLICENSEThe MIT License (MIT); Copyright Mike Tyers Labhttps://wiki.thebiogrid.org/doku.php/terms_and_conditions
- STRING: functional protein association networks
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licence
- Gene Curation Coalition (GenCC)LICENSEThe GenCC data are available free of restriction under a CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.https://thegencc.org/terms.htmlEOGT
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
- HUGO Gene Nomenclature Committee (HGNC)LICENSENo restrictions are imposed on access to, or use of, the data provided by the HGNC, which are provided to enhance knowledge and encourage progress in the scientific community.https://www.genenames.org/about/
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- NCBI Gene Expression Omnibus (GEO)
- NCBI MedGenLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- Online Mendelian Inheritance in Man (OMIM)LICENSEThe OMIM database is made available to the general public subject to certain restrictions.https://omim.org/help/copyright
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policies
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/about
- Swiss Institute of Bioinformatics Bgee
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics ResourceLICENSEAll data on VEuPathDB websites are provided freely for public use.https://veupathdb.org/veupathdb/app/static-content/about.html
- Wikidata
- Gene Ontology (GO)LICENSEGene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)http://geneontology.org/docs/go-citation-policy/Biological Processhttp://www.geneontology.org/
- AlphaFold DBLICENSEAll of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.https://alphafold.ebi.ac.uk/faq
- Rhea - annotated reactions databaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
CONTENTS