ENTPD6 - ectonucleoside triphosphate diphosphohydrolase 6 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions which are characteristic of NTPases. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Enables nucleoside diphosphate phosphatase activity. Predicted to be involved in nucleoside diphosphate catabolic process. Located in Golgi apparatus; extracellular region; and plasma membrane.
- CD39L2
- IL-6SAG
- IL6ST2
- NTPDase-6
- dJ738P15.3
- CD39 antigen-like 2
- NTPDase 6
- ectonucleoside triphosphate diphosphohydrolase 6 (putative)
- interleukin 6 signal transducer-2
Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PMID: 10948193, PMID: 11041856, PMID: 14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PMID: 10948193, PMID: 11041856, PMID: 14529283).
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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