ELOVL2 - ELOVL fatty acid elongase 2 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2024-12-31
Description
Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum.
- SSC2
- very long chain fatty acid elongase 2
- 3-keto acyl-CoA synthase ELOVL2
- ELOVL FA elongase 2
- elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
- elongation of very long chain fatty acids protein 2
- very long chain 3-ketoacyl-CoA synthase 2
- very long chain 3-oxoacyl-CoA synthase 2
- ELOVL2 (black-footed ferret)
- ELOVL2 (European mink)
- ELOVL2 (Ahaetulla prasina)
- ELOVL2 (red-backed fairy wren)
- ELOVL2 (Oenanthe melanoleuca)
- ELOVL2 (Chinese forest musk deer)
- ELOVL2 (raccoon dog)
- ELOVL2 (Leopard gecko)
- ELOVL2 (Pteronotus mesoamericanus)
- ELOVL2 (black-legged kittiwake)
- ELOVL2 (Aeolian wall lizard)
- ELOVL2 (graceful crag lizard)
- ELOVL2 (lesser prairie-chicken)
- ELOVL2 (takin)
- ELOVL2 (yellow-footed antechinus)
- ELOVL2 (California condor)
- ELOVL2 (Macaca thibetana thibetana)
- ELOVL2 (Northern goshawk)
- ELOVL2 (snow leopard)
- ELOVL2 (rock ptarmigan)
- ELOVL2 (Loggerhead turtle)
- ELOVL2 (Sphaerodactylus townsendi)
- ELOVL2 (Eurasian river otter)
- ELOVL2 (bobcat)
- ELOVL2 (greater spear-nosed bat)
- ELOVL2 (American black bear)
- ELOVL2 (Ring-tailed lemur)
- ELOVL2 (Agile Gracile Mouse Opossum)
- ELOVL2 (Komodo dragon)
- ELOVL2 (Asiatic toad)
- ELOVL2 (American mink)
- ELOVL2 (leopard cat)
- ELOVL2 (wapiti)
- ELOVL2 (fence lizard)
- ELOVL2 (Arctic fox)
- ELOVL2 (rufous-necked snowfinch)
- ELOVL2 (white-rumped snowfinch)
- ELOVL2 (jaguarundi)
- ELOVL2 (common toad)
- ELOVL2 (common frog)
- ELOVL2 (scimitar-horned oryx)
- ELOVL2 (Barn swallow)
- ELOVL2 (large flying fox)
- ELOVL2 (Eurasian tree sparrow)
- ELOVL2 (Reeves's turtle)
- ELOVL2 (Tiger rattlesnake)
- ELOVL2 (striped hyena)
- ELOVL2 (leatherback sea turtle)
- ELOVL2 (Iberian mole)
- ELOVL2 (Jamaican fruit-eating bat)
- ELOVL2 (Sturnira hondurensis)
- ELOVL2 (Kuhl's pipistrelle)
- ELOVL2 (Myotis myotis)
- ELOVL2 (Pallas's mastiff bat)
- ELOVL2 (black swan)
- ELOVL2 (common lizard)
- ELOVL2 (Southern elephant seal)
- ELOVL2 (Trachemys scripta elegans)
- ELOVL2 (Pantherophis guttatus)
- ELOVL2 (Gaboon caecilian)
- ELOVL2 (Francois's langur)
- ELOVL2 (greater horseshoe bat)
- ELOVL2 (Abingdon island giant tortoise)
- ELOVL2 (vaquita)
- ELOVL2 (tufted duck)
- ELOVL2 (silvery gibbon)
- ELOVL2 (ring-necked pheasant)
- ELOVL2 (Kakapo)
- ELOVL2 (Microcaecilia unicolor)
- ELOVL2 (Aquila chrysaetos chrysaetos)
- ELOVL2 (Common wall lizard)
- ELOVL2 (pale spear-nosed bat)
- ELOVL2 (Steller sea lion)
- ELOVL2 (willow flycatcher)
- ELOVL2 (California sea lion)
- ELOVL2 (burrowing owl)
- ELOVL2 (eastern brown snake)
- ELOVL2 (mainland tiger snake)
- ELOVL2 (brown bear)
- ELOVL2 (Okarito brown kiwi)
- ELOVL2 (Nothoprocta perdicaria)
- ELOVL2 (red fox)
- ELOVL2 (puma)
- ELOVL2 (dingo)
- ELOVL2 (gelada)
- ELOVL2 (Yangtze finless porpoise)
- ELOVL2 (common vampire bat)
- ELOVL2 (blue tit)
- ELOVL2 (Ugandan red Colobus)
- ELOVL2 (beluga whale)
- ELOVL2 (Hawaiian monk seal)
- ELOVL2 (white-rumped munia)
- ELOVL2 (helmeted guineafowl)
- ELOVL2 (koala)
- ELOVL2 (central bearded dragon)
- ELOVL2 (zebu cattle)
- ELOVL2 (great roundleaf bat)
- ELOVL2 (Australian saltwater crocodile)
- ELOVL2 (Gharial)
- ELOVL2 (leopard)
- ELOVL2 (Nanorana parkeri)
- ELOVL2 (black snub-nosed monkey)
- ELOVL2 (Malayan pangolin)
- ELOVL2 (Panamanian white-faced capuchin)
- ELOVL2 (Miniopterus natalensis)
- ELOVL2 (Egyptian rousette)
- ELOVL2 (Japanese quail)
- ELOVL2 (Taiwan habu)
- ELOVL2 (Great Tit)
- ELOVL2 (Gekko japonicus)
- ELOVL2 (cheetah)
- ELOVL2 (Common starling)
- ELOVL2 (ass)
- ELOVL2 (North Island brown kiwi)
- ELOVL2 (Swan goose)
- ELOVL2 (gray mouse lemur)
- ELOVL2 (Coquerel's sifaka)
- ELOVL2 (sooty mangabey)
- ELOVL2 (drill)
- ELOVL2 (Colobus angolensis palliatus)
- ELOVL2 (pig-tailed macaque)
- ELOVL2 (large flying fox)
- ELOVL2 (Arabian camel)
- ELOVL2 (Bactrian camel)
- ELOVL2 (Bison bison bison)
- ELOVL2 (bald eagle)
- ELOVL2 (Corvus cornix cornix)
- ELOVL2 (golden snub-nosed monkey)
- ELOVL2 (East African grey crowned-crane)
- ELOVL2 (White-tailed tropicbird)
- ELOVL2 (white-throated tinamou)
- ELOVL2 (brown roatelo)
- ELOVL2 (sunbittern)
- ELOVL2 (Buceros rhinoceros silvestris)
- ELOVL2 (Macqueen's bustard)
- ELOVL2 (Kea)
- ELOVL2 (chimney swift)
- ELOVL2 (red-crested turaco)
- ELOVL2 (common barn owl)
- ELOVL2 (cuckoo roller)
- ELOVL2 (hoatzin)
- ELOVL2 (Downy woodpecker)
- ELOVL2 (killdeer)
- ELOVL2 (bar-tailed trogon)
- ELOVL2 (red-throated loon)
- ELOVL2 (Red-legged seriema)
- ELOVL2 (African ostrich)
- ELOVL2 (little egret)
- ELOVL2 (Northern fulmar)
- ELOVL2 (common cuckoo)
- ELOVL2 (great cormorant)
- ELOVL2 (Dalmatian pelican)
- ELOVL2 (crested ibis)
- ELOVL2 (Adelie penguin)
- ELOVL2 (emperor penguin)
- ELOVL2 (Common canary)
- ELOVL2 (rifleman)
- ELOVL2 (carmine bee-eater)
- ELOVL2 (polar bear)
- ELOVL2 (American crow)
- ELOVL2 (Sunda flying lemur)
- ELOVL2 (Przewalski's horse)
- ELOVL2 (big brown bat)
- ELOVL2 (Philippine tarsier)
- ELOVL2 (green monkey)
- ELOVL2 (Yangtze River dolphin)
- ELOVL2 (Burmese python)
- ELOVL2 (minke whale)
- ELOVL2 (sperm whale)
- ELOVL2 (tiger)
- ELOVL2 (Green sea turtle)
- ELOVL2 (black flying fox)
- ELOVL2 (Myotis davidii)
- ELOVL2 (Weddell seal)
- ELOVL2 (American alligator)
- ELOVL2 (alpaca)
- ELOVL2 (Wild Bactrian camel)
- ELOVL2 (Chinese tree shrew)
- ELOVL2 (Chinese soft-shelled turtle)
- ELOVL2 (little brown bat)
- ELOVL2 (water buffalo)
- ELOVL2 (Chinese alligator)
- ELOVL2 (coelacanth)
- ELOVL2 (wild yak)
- ELOVL2 (Brandt's bat)
- ELOVL2 (goat)
- ELOVL2 (crab-eating macaque)
- ELOVL2 (Tibetan ground-tit)
- ELOVL2 (rock pigeon)
- ELOVL2 (white-throated sparrow)
- ELOVL2 (Saker falcon)
- ELOVL2 (medium ground-finch)
- Elovl2 (long-tailed chinchilla)
- ELOVL2 (western painted turtle)
- ELOVL2 (peregrine falcon)
- ELOVL2 (Collared flycatcher)
- ELOVL2 (mallard)
- ELOVL2 (domestic ferret)
- ELOVL2 (small Madagascar hedgehog)
- ELOVL2 (European shrew)
- ELOVL2 (American pika)
- ELOVL2 (nine-banded armadillo)
- ELOVL2 (Pacific walrus)
- ELOVL2 (killer whale)
- ELOVL2 (western lowland gorilla)
- ELOVL2 (sheep)
- ELOVL2 (domestic cat)
- ELOVL2 (Bolivian squirrel monkey)
- ELOVL2 (olive baboon)
- ELOVL2 (pygmy chimpanzee)
- ELOVL2 (small-eared galago)
- ELOVL2 (Tasmanian devil)
- ELOVL2 (African savanna elephant)
- ELOVL2 (northern white-cheeked gibbon)
- ELOVL2 (turkey)
- ELOVL2 (giant panda)
- ELOVL2 (Sumatran orangutan)
- ELOVL2 (white-tufted-ear marmoset)
- ELOVL2 (rabbit)
- ELOVL2 (zebra finch)
- ELOVL2 (pig)
- ELOVL2 (platypus)
- ELOVL2 (horse)
- ELOVL2 (gray short-tailed opossum)
- ELOVL2 (chimpanzee)
- ELOVL2 (Rhesus monkey)
- elovl2 (zebrafish)
- ELOVL2 (domestic cattle)
- elovl2 (tropical clawed frog)
- Elovl2 (Norway rat)
- ELOVL2 (dog)
- ELOVL2 (chicken)
- Elovl2 (house mouse)
Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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