Dsg4 - desmoglein 4 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-19
Description
This gene encodes a member of the cadherin family of proteins that forms an integral transmembrane component of desmosomes, the multiprotein complexes involved in cell adhesion, organization of the cytoskeleton, cell sorting and cell signaling. This gene is expressed in the suprabasal epidermis and hair follicle. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. Certain mutations in this gene are responsible for the lanceolate hair phenotype in mice. This gene is located in a cluster of desmosomal cadherin genes on chromosome 18. [provided by RefSeq, Feb 2016]
Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including BMP signaling pathway; hair follicle development; and keratinocyte differentiation. Located in desmosome. Is expressed in embryo; epidermis; and vibrissa. Used to study hypotrichosis 6. Human ortholog(s) of this gene implicated in hypotrichosis and hypotrichosis 6. Orthologous to human DSG4 (desmoglein 4).
- CDHF13
- lah
- desmoglein-4
A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PMID: 12705872). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (PMID: 12705872). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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