Dronc - Death regulator Nedd2-like caspase (fruit fly)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Enables cysteine-type endopeptidase activity and protein homodimerization activity. Involved in several processes, including nervous system development; programmed cell death involved in cell development; and protein processing. Located in cytoplasm; nucleus; and plasma membrane. Part of apoptosome. Is expressed in several structures, including clypeo-labral primordium; cystic bulge; germline cyst; gut section; and salivary gland. Used to study testicular cancer. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human CASP2 (caspase 2).
- CG8090
- CG8091
- DRONC
- Dmel\CG8091
- Dronc/Casp9
- Nc
- Nc\Dronc
- anon-EST:GreesD6
- anon-EST:GressD6
- anon-WO0118547.313
- caspase-9
- dronc
- death regulator Nedd2-like caspase
- CG8091-PA
- Caspase-9-like
- Dronc-PA
- Nedd2-like caspase
- caspase-9
- dronc
- drosophila Caspase-9 homologue
- drosophila Nedd2-like caspase
- nedd 2-like caspase
- Apoptotic Protease Activating Factor 3
- Caspase-9
- ICE-LAP6 Protein
- ICE-Like Apoptotic Protease 6
- Procaspase-9
- Pro-Caspase-9
Involved in the activation cascade of caspases responsible for apoptosis execution (PMID: 10200258, PMID: 10675329, PMID: 10984473). Effector of steroid-mediated apoptosis during insect metamorphosis (PMID: 10984473). Overexpression promotes programmed cell death (PMID: 10200258, PMID: 10675329, PMID: 10984473). Interaction with Diap1 is required to suppress Dronc-mediated cell death; via Diap1-mediated ubiquitination of Dronc (PMID: 10675329, PMID: 14517550). Rate-limiting caspase in rpr, grim and hid death pathway (PMID: 10984473, PMID: 14517550). Recruited to the Dark apoptosome, an adapter protein complex that mediates activation of the caspase cascade in programmed cell death initiated by the intrinsic apoptosis pathway (PMID: 21220123, PMID: 25644603). Association with the Dark apoptosome stimulates autocatalytic cleavage and activation of Dronc, promoting Dronc-mediated cleavage of downstream effector caspases such as Drice (PMID: 21220123, PMID: 25644603).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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