Dnase1l2 - deoxyribonuclease 1-like 2 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-20
Description
Predicted to enable DNA binding activity and deoxyribonuclease I activity. Acts upstream of or within DNA catabolic process; corneocyte development; and hair follicle development. Predicted to be located in cytoplasm and extracellular region. Predicted to be active in nucleus. Is expressed in several structures, including Harderian gland; alimentary system; brain; genitourinary system; and hemolymphoid system. Orthologous to human DNASE1L2 (deoxyribonuclease 1 like 2).
- 4733401H14Rik
- deoxyribonuclease-1-like 2
- DNase I-like 2
- deoxyribonuclease I-like 2
Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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