DMC1 - DNA meiotic recombinase 1 (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Enables ATP-dependent activity, acting on DNA and identical protein binding activity. Involved in reciprocal meiotic recombination. Located in nucleus.
- DMC1H
- LIM15
- dJ199H16.1
- meiotic recombination protein DMC1/LIM15 homolog
- DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
- disrupted meiotic cDNA1, yeast, homolog of
Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.
Isoform
UniProt ID
RefSeq Accession
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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