DEFB104A - defensin beta 104A (human)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-18
Description
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Oct 2014]
Enables chemoattractant activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; monocyte chemotaxis; and positive chemotaxis. Predicted to be located in extracellular region.
- BD-4
- DEFB-4
- DEFB104
- DEFB4
- hBD-4
- beta-defensin 104
- defensin, beta 4
Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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