Bcl10 - B cell leukemia/lymphoma 10 (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-28
Description
Enables CARD domain binding activity; identical protein binding activity; and signaling adaptor activity. Involved in several processes, including antifungal innate immune response; non-canonical NF-kappaB signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor).
- BCL-10
- CARMEN
- CIPER
- CLAP
- ME10
- cE10
- B-cell lymphoma/leukemia 10
- B-cell CLL/lymphoma 10
- CARD-containing molecule enhancing NF-kappa-B
- CARD-like apoptotic protein
- CED-3/ICH-1 prodomain homologous E10-like regulator
- cellular homolog of vCARMEN
- cellular-E10
- mammalian CARD-containing adapter molecule E10
Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation (PMID: 22265677). Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PMID: 22265677). Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex (By similarity). This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity (PMID: 22265677). Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR) (By similarity). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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