AKR1C1 - aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (Sumatran orangutan)
Gene
Symbol
Dates
- Create:2016-09-14
- Modify:2025-01-18
- aldo-keto reductase family 1 member C1
- 20-alpha-HSD
- 20-alpha-hydroxysteroid dehydrogenase
- aldo-keto reductase family 1 member C1 homolog
- indanol dehydrogenase
- 17 beta, 20 alpha-Hydroxysteroid Dehydrogenase
- 20 alpha-Hydroxysteroid Dehydrogenase
- 20-alpha-HSD
- NADPH-Dependent 20 alpha-Hydroxysteroid Oxidoreductase
- EC 1.1.1.- With NAD(+) or NADP(+) as acceptor
- EC 1.1.1.112 Indanol dehydrogenase
- EC 1.1.1.149 20-alpha-hydroxysteroid dehydrogenase
- EC 1.1.1.209 3(or 17)-alpha-hydroxysteroid dehydrogenase
- EC 1.1.1.210 3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase
- EC 1.1.1.357 3-alpha-hydroxysteroid 3-dehydrogenase
- EC 1.1.1.51 3(or 17)-beta-hydroxysteroid dehydrogenase
- EC 1.1.1.53 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase
- EC 1.1.1.62 17-beta-estradiol 17-dehydrogenase
- EC 1.3.1.20 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.
- NCBI GeneLICENSENCBI Website and Data Usage Policies and Disclaimershttps://www.ncbi.nlm.nih.gov/home/about/policies/
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html20-alpha-Hydroxysteroid Dehydrogenasehttps://meshb.nlm.nih.gov/record/ui?ui=D043607
- GlyCosmos Glycoscience PortalLICENSEAll copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.https://glycosmos.org/license
- UniProtLICENSEWe have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.https://www.uniprot.org/help/license
- Rhea - annotated reactions databaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
CONTENTS