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AKR1C1 - aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) (Sumatran orangutan)

Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-18

1 Names and Identifiers

1.1 Synonyms

  • aldo-keto reductase family 1 member C1
  • 20-alpha-HSD
  • 20-alpha-hydroxysteroid dehydrogenase
  • aldo-keto reductase family 1 member C1 homolog
  • indanol dehydrogenase

1.1.1 MeSH Entry Terms

  • 17 beta, 20 alpha-Hydroxysteroid Dehydrogenase
  • 20 alpha-Hydroxysteroid Dehydrogenase
  • 20-alpha-HSD
  • NADPH-Dependent 20 alpha-Hydroxysteroid Oxidoreductase

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 GlyCosmos Gene

2 Proteins

2.1 Protein Function

Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.

2.2 Protein Targets

3 Biochemical Reactions

4 Literature

4.1 NLM Curated PubMed Citations

4.2 Gene-Chemical Co-Occurrences in Literature

4.3 Gene-Gene Co-Occurrences in Literature

4.4 Gene-Disease Co-Occurrences in Literature

5 Patents

5.1 Gene-Chemical Co-Occurrences in Patents

5.2 Gene-Gene Co-Occurrences in Patents

5.3 Gene-Disease Co-Occurrences in Patents

6 Classification

6.1 MeSH Tree

7 Information Sources

  1. NCBI Gene
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    20-alpha-Hydroxysteroid Dehydrogenase
    https://meshb.nlm.nih.gov/record/ui?ui=D043607
  4. GlyCosmos Glycoscience Portal
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    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  6. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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