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waaO - UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase (Escherichia coli str. K-12 substr. MG1655)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-12
Description
The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11352].

1 Names and Identifiers

1.1 Synonyms

  • ECK3617
  • rfaI
  • waaI

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

1.2.2 GlyCosmos Gene

1.2.3 Wikidata

2 Proteins

2.1 Protein Function

Glucosyltransferase involved in the biosynthesis of the core oligosaccharide region of lipopolysaccharide (LPS) (PMID: 24479701, PMID: 9765561). Catalyzes the addition of a second glucose (glucose II) to the first outer-core glucose (glucose I) (PMID: 24479701, PMID: 9765561). In vitro, can add multiple glucose residues to its lipid acceptor (PMID: 24479701). Activity does not require the branched galactose added by WaaB, but it is higher in the presence of this branched galactose (PMID: 24479701). In the absence of a lipid acceptor, can hydrolyze UDP-glucose, but not UDP-galactose (PMID: 24479701).

2.2 Protein 3D Structures

2.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

2.3 Protein Targets

3 Interactions and Pathways

3.1 Interactions

3.2 Pathways

4 Biochemical Reactions

5 Expression

6 Literature

6.1 Consolidated References

6.2 Gene-Chemical Co-Occurrences in Literature

6.3 Gene-Gene Co-Occurrences in Literature

6.4 Gene-Disease Co-Occurrences in Literature

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Database of Interacting Proteins (DIP)
    LICENSE
    All DIP database records available under the terms set by the Creative Commons Attribution-NoDerivs License.
    https://dip.doe-mbi.ucla.edu/dip/termsofuse.html
  4. STRING: functional protein association networks
  5. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  6. NCBI Gene Expression Omnibus (GEO)
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. Wikidata
    UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase b3627
    https://www.wikidata.org/wiki/Q23086126
  9. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  10. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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