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ilvC - acetohydroxy-acid isomeroreductase (NADP-dependent) (Bacillus subtilis subsp. subtilis str. 168)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-20
Description
Please note that currently there is no data available in PubChem associated with ilvC - acetohydroxy-acid isomeroreductase (NADP-dependent) (Bacillus subtilis subsp. subtilis str. 168). However, annotations from external sources are available.

1 Names and Identifiers

1.1 Synonyms

BSU28290

1.2 Other Identifiers

1.2.1 Enzyme Commission (EC) Number

1.2.2 Wikidata

2 Proteins

2.1 Protein Function

Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.

2.2 Protein Targets

3 Biochemical Reactions

4 Expression

5 Literature

5.1 Gene-Chemical Co-Occurrences in Literature

5.2 Gene-Gene Co-Occurrences in Literature

5.3 Gene-Disease Co-Occurrences in Literature

6 Patents

6.1 Gene-Chemical Co-Occurrences in Patents

6.2 Gene-Gene Co-Occurrences in Patents

6.3 Gene-Disease Co-Occurrences in Patents

7 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. NCBI Gene Expression Omnibus (GEO)
  4. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  5. Wikidata
    ketol-acid reductoisomerase BSU28290
    https://www.wikidata.org/wiki/Q23350180
  6. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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