RAD4 - Rad4p (Saccharomyces cerevisiae S288C)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-03
Description
Enables single-strand break-containing DNA binding activity. Involved in DNA metabolic process; negative regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol and nucleus. Part of nucleotide-excision repair factor 2 complex. Used to study xeroderma pigmentosum. Human ortholog(s) of this gene implicated in pancreatic cancer; serous cystadenocarcinoma; xeroderma pigmentosum; and xeroderma pigmentosum group C. Orthologous to human XPC (XPC complex subunit, DNA damage recognition and repair factor).
Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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